ID   A0A2K5D4B1_AOTNA        Unreviewed;       828 AA.
AC   A0A2K5D4B1;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Leucine rich repeats and guanylate kinase domain containing {ECO:0000313|Ensembl:ENSANAP00000015778.1};
GN   Name=LRGUK {ECO:0000313|Ensembl:ENSANAP00000015778.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000015778.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000015778.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A2K5D4B1; -.
DR   STRING; 37293.ENSANAP00000015778; -.
DR   Ensembl; ENSANAT00000033620.1; ENSANAP00000015778.1; ENSANAG00000025769.1.
DR   GeneTree; ENSGT00940000157992; -.
DR   OMA; EEDGCDY; -.
DR   OrthoDB; 1331402at2759; -.
DR   Proteomes; UP000233020; Unplaced.
DR   CDD; cd00071; GMPK; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR025875; Leu-rich_rpt_4.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR23117; GUANYLATE KINASE-RELATED; 1.
DR   PANTHER; PTHR23117:SF18; LEUCINE-RICH REPEAT AND GUANYLATE KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   Pfam; PF12799; LRR_4; 1.
DR   Pfam; PF14580; LRR_9; 1.
DR   SMART; SM00072; GuKc; 1.
DR   SMART; SM00365; LRR_SD22; 7.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR   PROSITE; PS51450; LRR; 6.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT   DOMAIN          417..600
FT                   /note="Guanylate kinase-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50052"
FT   REGION          76..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          769..828
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        769..785
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   828 AA;  93347 MW;  4853BD521CF8BF41 CRC64;
     MAASESALLR TRAASLPRGL GRSPTGAQSL QFLVEEERQP CRSSFPMGHK TKGTFNTASS
     YLLQQLMHRY QELDADGDED LGEGEGEAGS EESSESEMLN LEEEFDGVLR EEAVAEALHQ
     LGRSGSGTEQ VYLNLTLSGC NLIDVSILCG YVHLQKLDLS ANKIEDLSCV SCMPYLLELN
     ASQNNLTTFF NFKPPKNLKK VDFSHNQISE ICDLSAYHAL TKLILDGNKI EEISGLEMCN
     NLTHLSLANN KITKINGLNT LPIKILCLSN NQIEMITGLE NLKVLQNVDL SHNQISSLRG
     LENHNLLEVI NLEDNKIAEL KEIEYIENLP ILRVLNLLKN PIQEKSEYWF FVIFVLLRLT
     ELDQKKIKVE EKVSAVNKYD PPPEVVAAQD HLTHVVNSVM QPQRIFDSTL PSLDAPYPML
     ILAGPEACGK RELAHRLCRQ FSTYFRYGAC HTTRPPYFGE GDRVDYHFIS QEVFDEMVNM
     GKFILTFSYG NHKYGLNRDT VEGIARDGLA SCIHMEIEGV RSLKYSYFEP RYILVVPMNK
     EKYEGYLRRK GLFSRAEIEF AVSRVDLYIK INQKFPGYFD AVINADDLDV AYQKLSQLIR
     EYLGLTEEPA KGLAATADVK TSHLKSEVHP TKYISSNMAD FLHSTDRNYL VKLWAKLSAK
     KTPVERASIH RQRESARQAL IGRIHPGHTL LFQRGPVPVP LTRGLHYNTT LEEPQKSFDV
     CEDYFKPPFG PHPEKSGKDS LVSMKCSLFR FCPWSKELPF QAPEGNISSH LGSGASDSET
     EETLKALPIQ SFAHEKESHQ HQRHSVPVIS HPGSNVKPTL PPIPQGRR
//