ID   A0A2K5D4D2_AOTNA        Unreviewed;       476 AA.
AC   A0A2K5D4D2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=StAR related lipid transfer domain containing 3 {ECO:0000313|Ensembl:ENSANAP00000015815.1};
GN   Name=STARD3 {ECO:0000313|Ensembl:ENSANAP00000015815.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000015815.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000015815.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the STARD3 family.
CC       {ECO:0000256|ARBA:ARBA00010909}.
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DR   AlphaFoldDB; A0A2K5D4D2; -.
DR   STRING; 37293.ENSANAP00000015815; -.
DR   Ensembl; ENSANAT00000033658.1; ENSANAP00000015815.1; ENSANAG00000025765.1.
DR   GeneTree; ENSGT00940000159051; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0140284; C:endoplasmic reticulum-endosome membrane contact site; IEA:Ensembl.
DR   GO; GO:0031902; C:late endosome membrane; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0015485; F:cholesterol binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0030301; P:cholesterol transport; IEA:Ensembl.
DR   GO; GO:0006701; P:progesterone biosynthetic process; IEA:Ensembl.
DR   GO; GO:0099044; P:vesicle tethering to endoplasmic reticulum; IEA:Ensembl.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR019498; MENTAL.
DR   InterPro; IPR000799; StAR-like.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   InterPro; IPR002913; START_lipid-bd_dom.
DR   PANTHER; PTHR46121:SF2; STAR-RELATED LIPID TRANSFER PROTEIN 3; 1.
DR   PANTHER; PTHR46121; STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE; 1.
DR   Pfam; PF10457; MENTAL; 2.
DR   Pfam; PF01852; START; 1.
DR   PRINTS; PR00978; STARPROTEIN.
DR   SMART; SM00234; START; 1.
DR   SUPFAM; SSF55961; Bet v1-like; 1.
DR   PROSITE; PS51439; MENTAL; 1.
DR   PROSITE; PS50848; START; 1.
PE   3: Inferred from homology;
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        52..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        122..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          46..191
FT                   /note="MENTAL"
FT                   /evidence="ECO:0000259|PROSITE:PS51439"
FT   DOMAIN          222..385
FT                   /note="START"
FT                   /evidence="ECO:0000259|PROSITE:PS50848"
FT   REGION          186..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          434..476
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   476 AA;  52320 MW;  289A29EAF3118508 CRC64;
     MSKLPGELGG DLERSLPALA SLGSSLSHSQ SLSSHFLLPP EKRRAISDVR RTFCLFVTFD
     LLFISLLWII ELNVLAFFRF SGLLLGYAVL RLRHWWVIAV TTLVSSAFLI VKVILSELLS
     KGAFGYLLPI VSFVLAWLET WFLDFKVLPQ EAEEDRWYLA AQAAVAHGPL LFSGTLSEGQ
     FYSPPESFAG SDNESDEEVS GKKSFSAQER EYVRQGKEAA AVVDQILAQE ENWKFEKNNE
     YGDTVYTIEV PFHGKTFILK TFLPCPAELV YQEVILQPEK MVLWNKTVTA CQILQRVEDN
     TLISYDVSAG AAGGVVSPRD FVNVRRIERR RDRYLSSGIA TTHGAKPPTH KYVRGENGPG
     GFIVLKSPSN PRVCTFIWIL NTDLKVGCWG AARAACPGTS FTRASRPPCL NLPFTCGSAS
     VSWGPGCDHA PTHPAGQGPV ATTSRARKGA GWALAAHTGP GPKLPSSTEP RSAWSR
//