ID A0A2K5D5B7_AOTNA Unreviewed; 1856 AA.
AC A0A2K5D5B7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Fer-1 like family member 6 {ECO:0000313|Ensembl:ENSANAP00000016156.1};
GN Name=FER1L6 {ECO:0000313|Ensembl:ENSANAP00000016156.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000016156.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000016156.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ferlin family.
CC {ECO:0000256|ARBA:ARBA00007561}.
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DR STRING; 37293.ENSANAP00000016156; -.
DR Ensembl; ENSANAT00000034001.1; ENSANAP00000016156.1; ENSANAG00000025928.1.
DR GeneTree; ENSGT00940000159069; -.
DR OMA; SPNEDMM; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 5.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF37; FER-1-LIKE 6 (C. ELEGANS); 1.
DR Pfam; PF00168; C2; 6.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 6.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 6.
DR PROSITE; PS50004; C2; 6.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1823..1842
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..183
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 221..355
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 809..936
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 968..1097
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1337..1456
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1577..1728
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 17..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1116..1150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1164..1201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1224..1245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 596..623
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 29..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..447
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1164..1188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1856 AA; 209187 MW; DC2C14EBD3368489 CRC64;
MFGLKLKKKK NKAEKGLILA NKAAKDSQGD TEAPQEEPSH QEGPGDLVHN DASIFPIPSA
PPKRRSKLLT KIHDGEVRSQ NYQIAITITE ARQLVGENID PVVTIEIGDE KKQSTVKEGT
NSPFYNEYFV FDFIGPQVHL FDKIIKISVF HHKLIGSVLI GSFKVDLGTV YNQPGHQFCD
KWALLTDPGD IRTGTKGYLK CDISVMGKGD VLKTNPKTSD AEEQIEKNLL IPDGFPSERP
WARFYVRLYK AEGLPKMNSS IMANVTKAFV GDSKDLVDPF VEVSFAGQTG RTTVQKNCAD
PVWHEQVIFK EMFPPLCRRV KIQVWDEGSM NDVALATHFI DLKKISNEQD GDKGFLPTFG
PAWINLYGSP RNHSLMDDYQ ELNEGFGEGV SFRGRILVEI AVEILSGGAQ ESKFSKALKE
FKLPSKDKDS KSSKGKDKAD KTDDGKSQQA SNKTNSTEVE VEPFDVPPEI VPEKSEEFLL
FGAFFEATMI DRKIGDKPIS FEVSIGNFGN LIDGGSHRGS KKSAESAEED LLPLLQEGQG
DAAHDAPIPM ASTTHPEKPL VTEGNRNYNY LPFEDKKPCV YFISSWGDQT FRLHWSNMLE
KMADFLEESI EEMRELIKIS EEAPEEKMKT VLSDFISQSS AFISEAEKKP KMLNQTTLDK
KRLTLCWQEL EAMCKEAKGI IQQQQKKLSL DEMIHEAQNF VEKIRFLIDE PQHTIPDVFI
WMLSNNKRVA YARIASKDLL YSPVTRQMGK HCGKIKTHFL KPPGKRPAGW SVQAKVDVYL
WLGSIKHASA ILDNLPAGYE AEMSSKGAGT NHPPSNLHYQ DRHIFQLRAH MYQARGLIAA
DSSGLSDPFA KVTFLSHCQT TKIISQTLSP TWNQMLLFND LVLHGDVKEL AESPPLVVVE
LYDSDAVGKP EYLGATVAAP VVKLADQDYE PPRLCYHPIF CGNLSGGDLL AVFELLQVPP
SGLQGLPPIE PPDITQIYPV PANIRPVLSK YRVEVLFWGV REMKKVQLLS VDRPQVLIEC
GGRGVKSCVI QSYKNNPNFS VQADAFEVEL PENELLHPPL SICVVDWRAF GRSTLVGTYT
INYLKQFLCK SREPLALISQ VDGTQVGDEI SESLTATESI GAPSASQDLP TDHIYVDVEP
PPTVVPDSAQ VQPAIVVDIP DSLPMLEPEH KPVAEEPPKD GKPKDPRTPS RRSTKRKKRT
IADESAENVI DWWSKYYASL KKAQKAKESN PKKKKGNMEA KPDEVVVDIE DGPKKKKDKM
LKKKLKDDGI PNLAVLQIYD GDLESEFNNF EDWVKTFELF RGKSTEDDHG LDGDRVIGKF
KGSFCIYKSP EDSSSEDGGQ LRIQQGIPLN HPVTVLIRVY IVAAFNLSPA DPDGKSDPYI
VIKLGKTEIK DRDKYIPKQL NPVFGRSFEI QATFPKESLL SILIYDHDMI GTDDLIGETK
IDLENRFYSK HRAICGLQSQ YEIEGYNAWR DTSKPTEILT KLCKDNKLDG PYFRPGKIQI
GKQVFSGKTV FTEEDTDETV ESYEHLALKV LHSWEDIPEV GCRLVPEHIE TRPLYHKDKP
GMEQGRLQMW VDMFPKDMPQ PGPPVDISPR RPKGYELRVT IWNTEDVILE DENIFTGQKS
SDIYVKGWLK GLEDDKQETD VHYNSLTGEG NFNWRFLFPF QYLPAEKQMV ITKRENIFSL
EKTECKTPAV LVLQVWDFER LSSDDFLGTL EMNLNSFPRA AKSAKACDLA KFENASEETK
ISIFQQKRVR GWWPFSKSKE LTGKVEAEFH LVTAEEAEKN PVGKARKEPE PLAKPNRPDT
SFSWFMSPFK CLYHLIWKNY KKYIIIGFIL IILIIFLVLF IYTLPGAISR RIVVGS
//
