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Database: UniProt
Entry: A0A2K5D5X0_AOTNA
LinkDB: A0A2K5D5X0_AOTNA
Original site: A0A2K5D5X0_AOTNA 
ID   A0A2K5D5X0_AOTNA        Unreviewed;       730 AA.
AC   A0A2K5D5X0;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Rap guanine nucleotide exchange factor 5 {ECO:0000313|Ensembl:ENSANAP00000016356.1};
GN   Name=RAPGEF5 {ECO:0000313|Ensembl:ENSANAP00000016356.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000016356.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000016356.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_012303211.1; XM_012447788.1.
DR   AlphaFoldDB; A0A2K5D5X0; -.
DR   STRING; 37293.ENSANAP00000016356; -.
DR   Ensembl; ENSANAT00000034203.1; ENSANAP00000016356.1; ENSANAG00000026030.1.
DR   GeneID; 105713959; -.
DR   CTD; 9771; -.
DR   GeneTree; ENSGT00940000155137; -.
DR   OMA; YQLHRRH; -.
DR   OrthoDB; 5473909at2759; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF26; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 5; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..730
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014328248"
FT   DOMAIN          218..351
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          495..729
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
SQ   SEQUENCE   730 AA;  84772 MW;  DB16E862AA36E143 CRC64;
     MAIGVWQLLL DMGIMLSVDQ HLYFQDTYVF YQFSSDECSY LYCEFEREEE WQNGVKLLLQ
     LVPLIPSRAG ICELSHQKIE DSEESSDEIL ARLTSAVQRE LAAVIALKAR KSAIEQDEEN
     NDKHVAVTEA ESVPDSQAGV MCKLQEKDEI GRIELVQKLA RENYQFLQTD KKEQEKSEHQ
     DDEVTTVQVK EQDQSVLVLK KVQCCGPAPT AGSAESHWRY VVVSGTPEKI LEHLLNDLHL
     EEVQDKETET LLDDFLLTYT VFMTTDDLCQ ALLRHYSAKK YQGKEENSDV PRRKRKVLHL
     VSQWIALYKD WLHEDEHSKM FLKTIYRNVL DDVYEYPILE KELKEFQKIL GMHRRHTVDE
     YSPQKKNKAL FHQFSLKENW LQHRGTVTET EEIFCHVYIT EHSYVSVKAK VSSIAQEILK
     VVAEKIQYAE EDLALVAITF SGEKHELQPN DLVISKSLEA SGRIYVYRKD LADTLNPFAE
     NEESQQRSMR ILGMNTWDLA LELMNFDWSL FNSIHEQELI YFTFSRQGSG EHTANLSLLL
     QRCNEVQLWV ATEILLCSQL GKRVQLVKKF IKIAAHCKAQ RNLNSFFAIV MGLNTASVSR
     LSQTWEKIPG KFKKLFSELE SLTDPSLNHK AYRDAFKKMK PPKIPFMPLL LKDVTFIHEG
     NKTFLDNLVN FEKLHMIADT VRTLRHCRTN QFGDLSPKEH QELKSYVNHL YVIDSQQALF
     ELSHRIEPRV
//
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