ID A0A2K5D6R6_AOTNA Unreviewed; 409 AA.
AC A0A2K5D6R6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Paired box protein Pax-9 {ECO:0000256|ARBA:ARBA00016206};
GN Name=PAX9 {ECO:0000313|Ensembl:ENSANAP00000016649.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000016649.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000016649.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Transcription factor required for normal development of
CC thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal
CC elements of skull and larynx as well as distal limbs.
CC {ECO:0000256|ARBA:ARBA00002731}.
CC -!- SUBUNIT: Interacts with KDM5B. {ECO:0000256|ARBA:ARBA00011734}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A2K5D6R6; -.
DR STRING; 37293.ENSANAP00000016649; -.
DR Ensembl; ENSANAT00000034501.1; ENSANAP00000016649.1; ENSANAG00000026186.1.
DR GeneTree; ENSGT00940000159896; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0071363; P:cellular response to growth factor stimulus; IEA:Ensembl.
DR GO; GO:0007492; P:endoderm development; IEA:Ensembl.
DR GO; GO:0060325; P:face morphogenesis; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0042476; P:odontogenesis; IEA:Ensembl.
DR GO; GO:0042481; P:regulation of odontogenesis; IEA:Ensembl.
DR CDD; cd00131; PAX; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR InterPro; IPR001523; Paired_dom.
DR InterPro; IPR043565; PAX_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45636; PAIRED BOX PROTEIN PAX-6-RELATED-RELATED; 1.
DR PANTHER; PTHR45636:SF13; PAIRED BOX PROTEIN PAX-9; 1.
DR Pfam; PF00292; PAX; 1.
DR PRINTS; PR00027; PAIREDBOX.
DR SMART; SM00351; PAX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00034; PAIRED_1; 1.
DR PROSITE; PS51057; PAIRED_2; 1.
PE 4: Predicted;
KW Paired box {ECO:0000256|ARBA:ARBA00022724};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 70..196
FT /note="Paired"
FT /evidence="ECO:0000259|PROSITE:PS51057"
SQ SEQUENCE 409 AA; 43898 MW; A9D111CCDA0AC79A CRC64;
MREGVRLDRD GWGRSALFRD RLAWGQPLSF VQDGCVRSVP GRAGRPSGRR LSQAAGARPR
ALCVRFLEPA FGEVNQLGGV FVNGRPLPNA IRLRIVELAQ LGIRPCDISR QLRVSHGCVS
KILARYNETG SILPGAIGGS KPRVTTPTVV KHIRTYKQRD PGIFAWEIRD RLLADGVCDK
YNVPSVSSIS RILRNKIGNL AQQGHYDSYK QHQPAPQPAL PYNHIYSYPS PITAAAAKVP
TPPGVPAIPG SVAMPRTWPS SHSVTDILGI RSITDQGRVS DSSPYHSTKV EEWSSLGRNN
FPAAAPHAVN GLEKGALEQE TKYGQAPNGL PAVGSFVSAS SMAPYPTPAQ VSPYMTYSAA
PSGYVAGHGW QHAGNTPLSP HNCDIPASLA FKGMQAAREG SHSVTASAL
//
