ID A0A2K5D8H3_AOTNA Unreviewed; 1136 AA.
AC A0A2K5D8H3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Replication factor C subunit 1 {ECO:0000256|PIRNR:PIRNR036578};
GN Name=RFC1 {ECO:0000313|Ensembl:ENSANAP00000017228.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000017228.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000017228.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR036578}.
CC -!- SIMILARITY: Belongs to the activator 1 large subunit family.
CC {ECO:0000256|ARBA:ARBA00006116, ECO:0000256|PIRNR:PIRNR036578}.
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DR AlphaFoldDB; A0A2K5D8H3; -.
DR STRING; 37293.ENSANAP00000017228; -.
DR Ensembl; ENSANAT00000035083.1; ENSANAP00000017228.1; ENSANAG00000026467.1.
DR GeneTree; ENSGT00730000111066; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005663; C:DNA replication factor C complex; IEA:Ensembl.
DR GO; GO:0031391; C:Elg1 RFC-like complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0061860; F:DNA clamp unloader activity; IEA:Ensembl.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:Ensembl.
DR CDD; cd17752; BRCT_RFC1; 1.
DR CDD; cd18140; HLD_clamp_RFC; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR013725; DNA_replication_fac_RFC1_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012178; RFC1.
DR InterPro; IPR047854; RFC_lid.
DR PANTHER; PTHR23389; CHROMOSOME TRANSMISSION FIDELITY FACTOR 18; 1.
DR PANTHER; PTHR23389:SF36; REPLICATION FACTOR C SUBUNIT 1; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF08519; RFC1; 1.
DR PIRSF; PIRSF036578; RFC1; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR036578};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR036578};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR036578}; Nucleus {ECO:0000256|PIRNR:PIRNR036578};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT DOMAIN 401..479
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 43..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1069..1136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..81
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..311
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1083..1098
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1099..1128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1136 AA; 127524 MW; BEC61FCB6C2D83B4 CRC64;
DIRKFFGVIP SGKKLVSETV KKSEKTKSDE ETLKAKKGIK EIKVNSSRKE DDLKQKQPNK
KKRIIYDSDS EPEETLQVKN AKKQPEKTPV SSKPGNISRQ DPVTYISETD EEDDFTCKKA
ASKSKENGRS TNSHLGTSDV KKNEENTKTK NKPLSPIKLT PTSVLDYFGT GSVQRSNKKM
VSSKRKEPSQ NTGDSGLNDE AIAKQLQLDE DAEVFRQLHE DEEFARTLAM LDEEPKTKKA
RKNTEEGETF SSVQASLSKA EKHKYPHKVK TEQFSDERKS YSPKKQTKYE SSKESQQHSK
SSTDKIREVS SPKASSKLAI MKKKEESSYT EIEPVASKRK ENAIELKGET KTPKKTKSSP
AKKESVSPED SEKKRTNYQA YRSYLNREGP KALGSKEIPK GAENCLEGLT FVITGVLESI
ERDEAKSLIE RYGGKVTGNV SKKTNYLVMG RDSGQSKSDK AAALGTKIID EDGLLNLIRT
MPGKKSKYEI AVEAEMKKES KLERTPQKNA QGKRKISPSK KESESKKSKL TSKRDSLAKT
IKKETDVFWR GLDFKEQVAE ETSGDSKARN LADDSSENKM ENLLWVDKYK PTSLKTIIGQ
QGDQSCANKL LRWLRNWHKS SSEDKKHGDF TTSFIFVYIG TYMRKSNGSF ICQQELGYSY
VELNASDTRS KNSLKAIVAE SLNNTSIKGF YSNGAASSVS TKHALIMDEV DGMAGNEDRG
GIQELIGLIK HTKIPIICMC NDRNHPKIRS LVHYCFDLRF QRPRVEQIKG AMMSIAFKEG
LKIPPPAMNE IILGANQDIR QVLHNLSMWC ARSKALTYDQ AKADSHRAKK DIKMGPFDVA
RKVFAAGEET AHMSLVDKSD LFFHDYSIAP LFVQENYIHV KPVAAGGDMK KHLMLLSRAA
DSICDGDLVD SQIRSKQNWS LLPTQAIYAS VLPGELMRGY MTQFPTFPGW LGKHSSTGKH
DRIVQDLALH MSLRTYSSKR TVNMDYLSHL RDALVQPLTS QGVDGVQDVV ALMDTYYLMK
EDFESIMEIS SWGGKPSPFS KLDPKVKAAF TRAYNKEAHL TPYSLQAIKA SRHSTSPSLD
SEYNEELNED DSQSDEKDQD AIETDAMIKK KTKSSKPSKP EKDKESRKGK GKSSKK
//
