ID   A0A2K5D8M7_AOTNA        Unreviewed;      1080 AA.
AC   A0A2K5D8M7;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=NLR family CARD domain containing 3 {ECO:0000313|Ensembl:ENSANAP00000017306.1};
GN   Name=NLRC3 {ECO:0000313|Ensembl:ENSANAP00000017306.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000017306.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000017306.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K5D8M7; -.
DR   STRING; 37293.ENSANAP00000017306; -.
DR   Ensembl; ENSANAT00000035162.1; ENSANAP00000017306.1; ENSANAG00000026530.1.
DR   GeneTree; ENSGT00940000159861; -.
DR   OMA; DFTQVET; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0007249; P:canonical NF-kappaB signal transduction; IEA:Ensembl.
DR   GO; GO:0043124; P:negative regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   GO; GO:1900226; P:negative regulation of NLRP3 inflammasome complex assembly; IEA:Ensembl.
DR   GO; GO:1901223; P:negative regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR   GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Ensembl.
DR   GO; GO:0042110; P:T cell activation; IEA:Ensembl.
DR   CDD; cd00116; LRR_RI; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR   PANTHER; PTHR24106:SF285; NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 3; 1.
DR   Pfam; PF13516; LRR_6; 10.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   SMART; SM00368; LRR_RI; 14.
DR   SUPFAM; SSF52047; RNI-like; 2.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT   DOMAIN          154..286
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   REGION          16..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          51..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1080 AA;  116490 MW;  7C1691C4586EDEC1 CRC64;
     VQAVFSQLLE VIPDSMRKQE VHTGREAGQG HGTGSPAEQV KALMDLLAGK GSQGSQALQA
     PDRMPDSPLG PCSNDSRMQR HREVLLSRVG GGLELGSPSH RLPSLLLVEG LTDLQLREHD
     FTQVEATRGG GCPARTVALD RLFLPLSRVS VPPRVSITIG VAGMGKTTLV RHFVRLWARG
     QVGKDFSLVL PLTFRDLNTH EKLCADRLVR SVFPHVGEPS LAVAAPARAL LILDGLDECR
     TPLDFSNTVA CTDPKKEIPV DHLITNIIRG NLFPEVSVWI TSRPSASGQI PGGLVDRMTQ
     IQGFSEEEIK VCLEQMFPED QALLGWVLSQ VQADRALYLM CTVPAFCRLT GAALGHLWRS
     RTGPQDAELW TPKTLCELYS WYFRMALSGE GQEKGKARPR IEQMAHSGRK MVGTLGRMAF
     HGLLKKKYVF YEQDMKAFGV DLALLQGTLC SCFLQREETL ASSVAYCFTH LSLQEFVAAA
     YYYGASRRAI FDLFTESGVS WPRLGFLTHF RSAAQRAMQV EDGRLDVFLR FLSGLLSPRV
     NVLLAGSLLA QGEHQAYRTQ VAELLQGCLR PDAAVCARAI NVLHCLQELQ HTELARSVEE
     AMESGALAGL TGPAHRAALA YLLQVSDTCA QEANLSLNLS QGVLQSLLPQ LLYCRKLRLD
     TNQFQDPVME LLGSVLSGKD CRIQKISLAE NQISNKGAKA LARSLLVNRS LTSLDLRSNS
     IGPQGAKGLA DALKINRTLT SLSLQGNTIR DDGARSMAEA LASNRTLSVL HLQKNSIGPM
     GAQWMADALK QNRSLKELML SSNSIGDGGA KALAEALKVN QGLESLDLQS NSISDTGVAA
     LMGALCTNQA LLSLSLRENS ISPEGAQAIA RALRANSTLK NLDLTANLLH DQGAQAIAVA
     VRENRALTSL HLQWNFIQAG AAQALGQALQ LNRSLTSLDL QENDIGDDGA CAVARALKVN
     TALTALYLQV ASIGAPGAQV LGEALAVNRT LEILDLRGNA IGVAGAKALA NALKVNSSLR
     RLNLQENSLG MDGVIFVATA LSGNHRLQHI NLQGNHIGDS GARMISEAIK TNAPTCTVEM
//