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Database: UniProt
Entry: A0A2K5D9A8_AOTNA
LinkDB: A0A2K5D9A8_AOTNA
Original site: A0A2K5D9A8_AOTNA 
ID   A0A2K5D9A8_AOTNA        Unreviewed;      1487 AA.
AC   A0A2K5D9A8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=GTPase activating protein and VPS9 domains 1 {ECO:0000313|Ensembl:ENSANAP00000017523.1};
GN   Name=GAPVD1 {ECO:0000313|Ensembl:ENSANAP00000017523.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000017523.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000017523.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC   -!- SIMILARITY: Belongs to the GAPVD1 family.
CC       {ECO:0000256|ARBA:ARBA00008489}.
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DR   RefSeq; XP_012313566.1; XM_012458143.1.
DR   STRING; 37293.ENSANAP00000017523; -.
DR   Ensembl; ENSANAT00000035381.1; ENSANAP00000017523.1; ENSANAG00000026547.1.
DR   GeneID; 105721197; -.
DR   CTD; 26130; -.
DR   GeneTree; ENSGT00940000156611; -.
DR   OMA; ENHEIML; -.
DR   OrthoDB; 20678at2759; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0032794; F:GTPase activating protein binding; IEA:Ensembl.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0051223; P:regulation of protein transport; IEA:Ensembl.
DR   CDD; cd05129; RasGAP_RAP6; 1.
DR   Gene3D; 1.10.246.120; -; 1.
DR   Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR   InterPro; IPR041545; DUF5601.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR003123; VPS9.
DR   InterPro; IPR045046; Vps9-like.
DR   InterPro; IPR037191; VPS9_dom_sf.
DR   PANTHER; PTHR23101:SF25; GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR   Pfam; PF18151; DUF5601; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   Pfam; PF02204; VPS9; 1.
DR   SMART; SM00167; VPS9; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF109993; VPS9 domain; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR   PROSITE; PS51205; VPS9; 1.
PE   3: Inferred from homology;
KW   Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT   DOMAIN          144..353
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   DOMAIN          1347..1487
FT                   /note="VPS9"
FT                   /evidence="ECO:0000259|PROSITE:PS51205"
FT   REGION          574..608
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          739..769
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          921..954
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          967..1050
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        574..592
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        740..769
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        982..1006
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1018..1038
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1487 AA;  166212 MW;  0E0DA108340397B3 CRC64;
     MVKLDIHTLA HHLKQERLYV NSEKQLIQRL NADVLKTAEK LYRTAWIAKQ QRINLDRLII
     TSAEASPAEC CQHAKILEDT QFVDGYKQLG FQETAYGEFL SRLRENPRLI ASSLVAGEKL
     NQENTQSVIY TVFTSLYGNC IMQEDESYLL QVLRYLIEFE LKESDNPRRL LRRGTCAFSI
     LFKLFSEGLF SAKLFLTATL HEPIMQLLVE DEDHLETDPN KLIERFSPSQ QEKLFGEKGS
     DRFRQKVQEM VESNEAKLVA LVNKFIGYLK QNTYCFPHSL RWIVSQMYKT LSCVDRLEVG
     EVRAMCTDLL LACFICPAVV NPEQYGIISD APINEVARFN LMQVGRLLQQ LAMTGSEEGD
     PRTKSSLGKF DKSCVAAFLD VVIGGRAVET PPLSSVNLLE GLSRTVVYIT YSQLITLVNF
     MKSVMSGDQL REDRMALDNL LANLPPAKPG KSSSLEMTPY NTPQLSPATT PANKKNRLPI
     ATRSRSRTNM LMDLHMDHEG SSQETIQEVQ PEEVLVISLG TGPQLTPGMM SENEVLNMQL
     SDGGQGDVPV DENKLHGKPD KTLRFSLCSD NLEGISEGPS NRSNSVSSLD LEGESVSELG
     AGPSGSNGVE ALQLLEHEQA TTQDNLDDKL RKFEIRDMMG LTDDRDISET VSETWSTDVL
     GSDFDPNIDE DRLQEIAGAA AENMLGSLLC LPGSGSVLLD PCTGSTISET TSEAWSVEVL
     PSDSEAPDLK QEERLQELES CSGLGSTSDD TDVREVSSRP STPGLSVVSG ISATSEDIPN
     KIEDLRSECS SDFGGKDSVT SPDMDEITHD FLYILQPQQH FQHIEAEADM RIQLCSSAHQ
     LTSPPSQSES LLAMFDPLSS HEGASAVVRP KVHYARPSHP PPDPPILEGA VGGNEARLPN
     FGSHVLTPAE MEAFKQRHSY PERLVRSRSS DIVSSVRRPM SDPSWNRRPG NEERELPPAA
     AIGATSLVAA PHSSSSSPSK DSSRGETEER KDSDDEKSDR NRPWWRKRFV SAMPKAPIPF
     RKKEKQEKDK DDLGPDRFST LTDDPSPRLS AQAQVAEDIL DKYRNAIKRT SPSDGAMANY
     ESTEVMGDGE SAHDSPREEA LQNISADDLP DSASQAAHPQ DSAFSYRDAK KKLRLALCSA
     DSVAFPVLTH TTRNGLPDHT DPEDNEIVCF LKVQIAEAIN LQDKNLMAQL QETMRCVCRF
     DNRTCRKLLA SIAEDYRKRA PYIAYLTRCR QGLQTTQAHL ERLLQRVLRD KEVANRYFTT
     VCVRLLLESK EKKIREFIQD FQKLTAADDK TAQVEDFLQF LYGAMAQDVI WQNASEEQLQ
     DAQLAIERSV MNRIFKLAFY PNQDGDILRD QVLHEHIQRL SKVVTANHRA LQIPEVYLRE
     APWPSAQSEI RTISAYKTPR DKVQCILRMC STIMNLLSLA NEDSVPGADD FVPVLVFVLI
     KANPPCLLST VQYISSFYAS CLSGEESYWW MQFTAAVEFI KTIDDRK
//
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