ID A0A2K5DC83_AOTNA Unreviewed; 310 AA.
AC A0A2K5DC83;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Homeostatic iron regulator {ECO:0000313|Ensembl:ENSANAP00000018558.1};
GN Name=HFE {ECO:0000313|Ensembl:ENSANAP00000018558.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000018558.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000018558.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Binds to transferrin receptor (TFR) and reduces its affinity
CC for iron-loaded transferrin. {ECO:0000256|ARBA:ARBA00003622}.
CC -!- SUBUNIT: Binds TFR through the extracellular domain in a pH-dependent
CC manner. {ECO:0000256|ARBA:ARBA00011632}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the MHC class I family.
CC {ECO:0000256|RuleBase:RU004439}.
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DR RefSeq; XP_012313983.1; XM_012458560.1.
DR AlphaFoldDB; A0A2K5DC83; -.
DR Ensembl; ENSANAT00000036421.1; ENSANAP00000018558.1; ENSANAG00000027106.1.
DR GeneID; 105721486; -.
DR CTD; 3077; -.
DR GeneTree; ENSGT01100000263517; -.
DR OrthoDB; 3840485at2759; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR GO; GO:0006826; P:iron ion transport; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR001039; MHC_I_a_a1/a2.
DR PANTHER; PTHR16675:SF172; HEREDITARY HEMOCHROMATOSIS PROTEIN; 1.
DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR PRINTS; PR01638; MHCCLASSI.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron transport {ECO:0000256|ARBA:ARBA00022496};
KW MHC I {ECO:0000256|ARBA:ARBA00022451};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..310
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014338242"
FT DOMAIN 207..286
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 310 AA; 35734 MW; 4BB9F3D4EABD0D9B CRC64;
MSPRARPELL LLMLLQTAVP QGRLLRSHSL HYLFMGASEQ DLGLSLFEAL GYVDDRLFVF
YDHESRRVEP RTPWVSSRTS SQMWLQLSQS LKGWDHMFTV DFWTIMDNHN HSKESHTLQV
ILGCEMKEDN STKGFWKYGY DGQNHLEFCS DTLDWRAAEP GAWPTKLEWE AHKIRARQNR
AYLERDCPAQ LQQLLELGRG VLDQQVPPLV KVTHHVTSSV TTLRCRALNF YPRNITMKWL
KDRQPLNAEE VEPKDVLPNG DGTYQGWIAL AVPAGEEQRY TCQVEHPGLD QPLLVIWGGA
MGQYVLAECE
//
