ID A0A2K5DDA4_AOTNA Unreviewed; 1870 AA.
AC A0A2K5DDA4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Plexin A3 {ECO:0000313|Ensembl:ENSANAP00000018924.1};
GN Name=PLXNA3 {ECO:0000313|Ensembl:ENSANAP00000018924.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000018924.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000018924.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR RefSeq; XP_012322469.1; XM_012467046.1.
DR Ensembl; ENSANAT00000036792.1; ENSANAP00000018924.1; ENSANAG00000027264.1.
DR GeneID; 105727265; -.
DR CTD; 55558; -.
DR GeneTree; ENSGT01050000244850; -.
DR OMA; CTHRLAP; -.
DR OrthoDB; 1387371at2759; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR CDD; cd12790; RasGAP_plexin_A; 1.
DR CDD; cd11273; Sema_plexin_A3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF32; PLEXIN-A3; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 3.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 4.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 4.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 4.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1870
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014361064"
FT DOMAIN 6..487
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT COILED 1238..1272
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1870 AA; 207690 MW; 9EFA599D10EA29A2 CRC64;
MPSVCLLLLL FLAVGGVLGN RPFRAFVVTD TTLTHLAVHR VTGEVFVGAV NRVFKLAPNL
TELRAHVTGP VEDNARCYPP PSMRVCAHRL APVNNVNKLL LIDYAARRLV ACGSIWQGIC
QFLRLDDLFK LGEPHHRKEH YLSGAQEPDS MAGVIVEQGQ GPSKLFVGTA VDGKSEYFPT
LSSRKLISDE DSADMFSLVY QDEFVSSQIK IPSDTLSLYP AFDIYYIYGF VSASFVYFLT
LQLDTQQTLL DTAGEKFFTS KIVRMCAGDS EFYSYVEFPI GCSWRGVEYR LVQSAHLAKP
GLLLAQALGV PADEDVLFTI FSQGQKNRAS PPRQTILCLF TLSNINAHIR RRIQSCYRGE
GTLALPWLLN KELPCINTPM QINGNFCGLV LNQPLGGLHV IEGLPLVADT DGMASVAAYT
YRQHSVVFIG TRSGSLKKVR VDGSQDAHLY ETVPVVDGSP ILRDLLFSPD HQHIYLLSEK
QVSQLPVETC EQYQSCAACL GSGDPHCGWC VLQHRCCREG ACPGASVPHG FAEELSKCVQ
VRVRPNNVSV TSPGVPLTVA LHNVPDLSAG VSCTFEEAAE SEAVLLPSSE LRCPSPSLQE
LRALTRGHGA VRTVRLQLLS KETGVRFADA DFVFYNCTVL QSCMSCVGSL YPCHWCKYRH
VCTSRPHECS FQEGRVHSPE GCPEILPSGD LLIPVGVMQP LTLRAKNLPQ PQSGQKNYEC
VVWVQGRQQR VPAVRFNSSS VQCQNASYSY EGDDYGDAEL DFSVVWDGHF PIDKPPSFRA
LLYKCWAQRP SCGLCLKADP RFNCGWCISQ HRCQLRTHCP APRTNWMHPS QKGARCSHPR
ITQIHPLVGP KEGGTWVTIV GENLGLLSRE VGLRVAGVRC NSIPAEYVSA ERIVCEMEES
LVPSPLPGPV ELCVGDCSAD FRAQSEQLYS FVTPAFDRVS PSRGPASGGT RLTISGSSLD
AGSRVTVTVR DGECQFVRRD AQSIVCLSPV STLGPSQAPI TLAIDRANIS SPGVMYTYTQ
DPTVTRLEPT WSIINGSTAI TVSGTHLLTV QEPRVRAKYR GIETTNTCQV INDTAMLCKA
PGIFLGRPQP RAQGEHPDEF GFLLDHVQTA RSLNRSSFTY YPDPSFEPLG PSGVLDVKPG
SHVVLKGKNL VPAAAGSSRL NYTVLIGGQP CALTVSDTQL LCDLPSQTGR QPVMVLVGGL
EFWLGTLHIS AERALTLPAM VGLAAGGGLL LLAITAVLVA YKRKTQDADR TLKRLQLQMD
NLESRVALEC KEAFAELQTD INELTNHMDE VQIPFLDYRT YAVRVLFPGI EAHPVLKELD
TPPNVEKALR LFGQLLYSRA FVLTFIHTLE AQSSFSMRDR GTVASLTMVV LQSRLDYATG
LLKQLLADLI EKNLESKNHP KLLLRRTESV AEKMLTNWFT FLLHKFLKEC AGEPLFLLYC
AIKQQMEKGP IDAITGEARY SLSEDKLIRQ QIDYKTLTLH CVCPENEGNA QVPVKVLNCD
SITQAKDKLL DTVYKGIPYS QRPKAEDMDL EWRQGRMTRV VLQDEDVTTK IECDWKRLNS
LAHYQVTDGS LVALVPKQVS AYNMANSFTF TRSLSRYESL LRTASSPDSL RSRAPMITPD
QETGTKLWHL VKNHDHADHR EGDRGSKMVS EIYLTRLLAT KGTLQKFVDD LFETVFSTAH
RGSALPLAIK YMFDFLDEQA DQRQISDPDV RHTWKSNCLP LRFWVNVIKN PQFVFDIHKN
SITDACLSVV AQTFMDSCST SEHRLGKDSP SNKLLYAKDI PNYKSWVERY YRDIAKMASI
SDQDMDAYLV EQSRLHASDF NVLSALSELY FYVTKYRQEI LTALDRDASC RKHKLRQNLE
QIISLVSSDS
//
