ID   A0A2K5DDM0_AOTNA        Unreviewed;      1018 AA.
AC   A0A2K5DDM0;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=IQ motif containing GTPase activating protein 2 {ECO:0000313|Ensembl:ENSANAP00000019062.1};
GN   Name=IQGAP2 {ECO:0000313|Ensembl:ENSANAP00000019062.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000019062.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000019062.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K5DDM0; -.
DR   Ensembl; ENSANAT00000036930.1; ENSANAP00000019062.1; ENSANAG00000027336.1.
DR   GeneTree; ENSGT00950000183076; -.
DR   Proteomes; UP000233020; Unplaced.
DR   CDD; cd05131; RasGAP_IQGAP2; 1.
DR   Gene3D; 1.20.5.190; -; 1.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR000593; RasGAP_C.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR   PANTHER; PTHR14149:SF12; RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP2; 1.
DR   Pfam; PF00612; IQ; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   Pfam; PF03836; RasGAP_C; 1.
DR   SMART; SM00015; IQ; 2.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF143885; RGC domain-like; 1.
DR   PROSITE; PS50096; IQ; 2.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT   DOMAIN          360..593
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   COILED          854..881
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1018 AA;  116890 MW;  AF834FA872A50400 CRC64;
     MHSFPGIVAV GYINEAIDEG NPSRTLETLL LPTANISDVD PAHAQHYQDV LYHAKSQKLR
     DSESVSKVLW LDEIQQAVDE ANVDEDRAKQ WITLVVDVNQ CLEGKKSSDI LSTLKSSTCN
     SNDIIPECAD RYYDALMKAK ELKSEMGKFV FYSAQTKYFK YNFYKYCFFN ILGFFLLYFK
     FWVTCTECAF WKGYKQQKEY MHRRQTFIDN TDSIVKIQSW FRMATARKSY LSRLQYFRDH
     NNEIVKIQSL LRANKARDDY KTLVGSENPP LTVIRKFVYL LDQSDLDFQE ELEVARLREE
     VVTKIRANQQ LEKDLNLMDI KIGLLVKNRI TLEVSGTNPL YLAKLIFQMP QNKSTKFMDT
     VIFTLYNYAS NQREEYLLLK LFKTALEEEI KSKVDQVQDI VTGNPTVIKM VVSFNRGARG
     QNTLRQLLAP VVKEIIDDKS LIINTNPVEV YKAWVNQLET QTGEASKLPY DVTTEQALTY
     PEVKNKLEAS IENLRRVTNK VLNSIISSLD LLPYGLRYIA KVLKNSIHEK FPDATEDELL
     KIVGNLLYYR YMNPAIVAPD GFDIIDMTAG GQINSDQRRN LGSVAKVLQH AASNKLFEGE
     NEHLSSMNNY LSETYQEFRK YFKEACNVPE PEEKFNMDKY TDLVTVSKPV IYISIEEIIS
     THSLLLEHQD AIAPEKNDLL SELLGSLGEV PTVESFLGEG AVDPNDPNKA NTLSQLSKTE
     ISLVLTSKYD IEDGEAIDSR SLMIKTKKLI IDVIRNQPGN TLAEILETPA TAQQEVDHAS
     DMVSRARIDS RTPEEMKHSQ SMIEDAQLPL EQKKRKIQRN LRTLEQTGHV SSKNKYQDIL
     NEIAKDIRNQ RIYRKLRKAE LAKLQQTLNA LNKKAAFYEE QINYYDTYIK TCLDNLKRKN
     ARRSIKLDGK GEPKGAKRAK PVKYTAAKLH EKGVLLGIDD LQTNQFKNVT FDIIATEDVG
     IFDVRSKFLG VEMEKVQLNI QDLLQMQYEG VAVMKMFDKV KVNVNLLIYL LNKKFYGK
//