ID   A0A2K5DF49_AOTNA        Unreviewed;       720 AA.
AC   A0A2K5DF49;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Exostosin glycosyltransferase 2 {ECO:0000313|Ensembl:ENSANAP00000019555.1};
GN   Name=EXT2 {ECO:0000313|Ensembl:ENSANAP00000019555.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000019555.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000019555.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004648}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 47 family.
CC       {ECO:0000256|ARBA:ARBA00010271}.
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DR   AlphaFoldDB; A0A2K5DF49; -.
DR   Ensembl; ENSANAT00000037428.1; ENSANAP00000019555.1; ENSANAG00000027569.1.
DR   GeneTree; ENSGT00940000156620; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016757; F:glycosyltransferase activity; IEA:InterPro.
DR   GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:UniProt.
DR   GO; GO:0006486; P:protein glycosylation; IEA:InterPro.
DR   InterPro; IPR004263; Exostosin.
DR   InterPro; IPR040911; Exostosin_GT47.
DR   InterPro; IPR015338; GT64.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR48261; ACETYLGLUCOSAMINYLTRANSFERASE; 1.
DR   PANTHER; PTHR48261:SF2; EXOSTOSIN-1-LIKE; 1.
DR   Pfam; PF03016; Exostosin; 1.
DR   Pfam; PF09258; Glyco_transf_64; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        24..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          101..380
FT                   /note="Exostosin GT47"
FT                   /evidence="ECO:0000259|Pfam:PF03016"
FT   DOMAIN          458..703
FT                   /note="Glycosyl transferase 64"
FT                   /evidence="ECO:0000259|Pfam:PF09258"
SQ   SEQUENCE   720 AA;  82268 MW;  E4CFADD1BF57C018 CRC64;
     MCASVKYNIR GPALIPRMKT KHRIYYITLF SIVLLGLIAT GMFQFWPHSI ESSNDWNVEK
     RSVRDVPVVR LPADSPIPER GDLSCRMHTC FDVYRCGFNP KNKIKVYIYA LKKYVDDFGV
     PVSNTISREY NELLTAISDS DYYTDDINRA CLFVPSIDVL NQNTLRIKET AQALAQLSRW
     DRGTNHLLFN MLPGGPPDYN TALDVPRDRA LLAGGGFSTW TYRQGYDVSI PVYSPLSAEV
     DLPEKGPGPR RYFLLSSQVG LHPEYREDVE ALQVKHGESV LVLDKCTNLS EGVLSVRKRC
     HKHQVFDYPQ VLQEATFCVV LRGARLGQAV LSDVLQAGCV PVVIADSYIL PFSEVLDWKR
     ASVVVPEEKM SDVYSILQSI PQRQIEEMQR QVRGQPRREN WSASIKAIAL ATLQIINDRI
     YPYAAISYEE WNDPPAVKWG SVSNPLFLPL IPPQSQGFTA IVLTYDRVES LFRVITEVSK
     VPSLSKLLVV WNNQNKNPPE DSLWPKIRVP LKVVRTAENK LSNRFFPYDE IETEAVLAID
     DDIIMLTSDE LQFGYEVWRE FPDRLVGYPG RLHLWDHEMN KWKYESEWTN EVSMVLTGAA
     FYHKYFNYLY TYKMPGDIKN WVDAHMNCED IAMNFLVANV TGKAVIKVTP RKKFKCPECT
     AIDGLSLDQT HMVERSECIN KFASVFGTMP LKVVEHRADP VLYKDDFPEK LKSFPNIGSL
//