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Database: UniProt
Entry: A0A2K5DFH4_AOTNA
LinkDB: A0A2K5DFH4_AOTNA
Original site: A0A2K5DFH4_AOTNA 
ID   A0A2K5DFH4_AOTNA        Unreviewed;       148 AA.
AC   A0A2K5DFH4;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=Caveolin {ECO:0000256|RuleBase:RU000680};
GN   Name=CAV3 {ECO:0000313|Ensembl:ENSANAP00000019680.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000019680.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000019680.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: May act as a scaffolding protein within caveolar membranes.
CC       Interacts directly with G-protein alpha subunits and can functionally
CC       regulate their activity. {ECO:0000256|RuleBase:RU000680}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC       {ECO:0000256|ARBA:ARBA00004135}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|RuleBase:RU000680};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202,
CC       ECO:0000256|RuleBase:RU000680}. Golgi apparatus membrane
CC       {ECO:0000256|RuleBase:RU000680}; Peripheral membrane protein
CC       {ECO:0000256|RuleBase:RU000680}. Membrane, caveola
CC       {ECO:0000256|RuleBase:RU000680}; Peripheral membrane protein
CC       {ECO:0000256|RuleBase:RU000680}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}.
CC   -!- SIMILARITY: Belongs to the caveolin family.
CC       {ECO:0000256|ARBA:ARBA00010988, ECO:0000256|RuleBase:RU000680}.
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DR   RefSeq; XP_012326537.1; XM_012471114.1.
DR   RefSeq; XP_012326538.1; XM_012471115.1.
DR   RefSeq; XP_012326548.1; XM_012471125.1.
DR   AlphaFoldDB; A0A2K5DFH4; -.
DR   STRING; 37293.ENSANAP00000019680; -.
DR   Ensembl; ENSANAT00000037553.1; ENSANAP00000019680.1; ENSANAG00000027621.1.
DR   GeneID; 105730113; -.
DR   CTD; 859; -.
DR   GeneTree; ENSGT00950000183006; -.
DR   OMA; MCSSIKV; -.
DR   OrthoDB; 3740765at2759; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0005901; C:caveola; IEA:UniProtKB-SubCell.
DR   GO; GO:0016010; C:dystrophin-associated glycoprotein complex; IEA:Ensembl.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0043014; F:alpha-tubulin binding; IEA:Ensembl.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:Ensembl.
DR   GO; GO:0071253; F:connexin binding; IEA:Ensembl.
DR   GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR   GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:Ensembl.
DR   GO; GO:0044325; F:transmembrane transporter binding; IEA:Ensembl.
DR   GO; GO:0007015; P:actin filament organization; IEA:Ensembl.
DR   GO; GO:0006816; P:calcium ion transport; IEA:Ensembl.
DR   GO; GO:0055013; P:cardiac muscle cell development; IEA:Ensembl.
DR   GO; GO:0003300; P:cardiac muscle hypertrophy; IEA:Ensembl.
DR   GO; GO:0070836; P:caveola assembly; IEA:Ensembl.
DR   GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
DR   GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:Ensembl.
DR   GO; GO:0035995; P:detection of muscle stretch; IEA:Ensembl.
DR   GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR   GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR   GO; GO:0060347; P:heart trabecula formation; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0007520; P:myoblast fusion; IEA:Ensembl.
DR   GO; GO:0051926; P:negative regulation of calcium ion transport; IEA:Ensembl.
DR   GO; GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IEA:Ensembl.
DR   GO; GO:0045792; P:negative regulation of cell size; IEA:Ensembl.
DR   GO; GO:0043409; P:negative regulation of MAPK cascade; IEA:Ensembl.
DR   GO; GO:1900826; P:negative regulation of membrane depolarization during cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0060299; P:negative regulation of sarcomere organization; IEA:Ensembl.
DR   GO; GO:0051647; P:nucleus localization; IEA:Ensembl.
DR   GO; GO:0001778; P:plasma membrane repair; IEA:Ensembl.
DR   GO; GO:0010831; P:positive regulation of myotube differentiation; IEA:Ensembl.
DR   GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR   GO; GO:0060762; P:regulation of branching involved in mammary gland duct morphogenesis; IEA:Ensembl.
DR   GO; GO:0090279; P:regulation of calcium ion import; IEA:Ensembl.
DR   GO; GO:0098909; P:regulation of cardiac muscle cell action potential involved in regulation of contraction; IEA:Ensembl.
DR   GO; GO:0002027; P:regulation of heart rate; IEA:Ensembl.
DR   GO; GO:1900744; P:regulation of p38MAPK cascade; IEA:Ensembl.
DR   GO; GO:0051896; P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR   GO; GO:0038009; P:regulation of signal transduction by receptor internalization; IEA:Ensembl.
DR   GO; GO:0014819; P:regulation of skeletal muscle contraction; IEA:Ensembl.
DR   GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0060373; P:regulation of ventricular cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR   GO; GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IEA:Ensembl.
DR   GO; GO:0006641; P:triglyceride metabolic process; IEA:Ensembl.
DR   InterPro; IPR001612; Caveolin.
DR   InterPro; IPR018361; Caveolin_CS.
DR   PANTHER; PTHR10844; CAVEOLIN; 1.
DR   PANTHER; PTHR10844:SF16; CAVEOLIN-3; 1.
DR   Pfam; PF01146; Caveolin; 1.
DR   PROSITE; PS01210; CAVEOLIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|RuleBase:RU000680};
KW   Golgi apparatus {ECO:0000256|RuleBase:RU000680};
KW   Membrane {ECO:0000256|RuleBase:RU000680, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        76..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   148 AA;  16892 MW;  9B46CACD88CF9901 CRC64;
     MMAEDLEAQI VKDIHCKEID LVNRDPKNIN EDIVKVDFED VIAEPVGTYS FDGVWKVSYT
     TFTVSKYWCY RLLSTLLGVP LALLWGFLFA CISFCHIWAV VPCIKSYLIE IQCISHIYSL
     CIRTFCNPLF AALGQVCSSI KVVLRKEV
//
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