ID A0A2K5DGU8_AOTNA Unreviewed; 615 AA.
AC A0A2K5DGU8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=HIC ZBTB transcriptional repressor 2 {ECO:0000313|Ensembl:ENSANAP00000020152.1};
GN Name=HIC2 {ECO:0000313|Ensembl:ENSANAP00000020152.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000020152.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000020152.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_012321921.1; XM_012466498.1.
DR RefSeq; XP_012321922.1; XM_012466499.1.
DR AlphaFoldDB; A0A2K5DGU8; -.
DR STRING; 37293.ENSANAP00000020152; -.
DR Ensembl; ENSANAT00000038027.1; ENSANAP00000020152.1; ENSANAG00000027852.1.
DR GeneID; 105726915; -.
DR CTD; 23119; -.
DR GeneTree; ENSGT00940000159978; -.
DR OMA; GTPNEPM; -.
DR OrthoDB; 1378030at2759; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR CDD; cd18334; BTB_POZ_ZBTB30_HIC2; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24394:SF22; HYPERMETHYLATED IN CANCER 2 PROTEIN; 1.
DR PANTHER; PTHR24394; ZINC FINGER PROTEIN; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 46..109
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT DOMAIN 442..469
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 505..532
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 533..560
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 561..588
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 589..615
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 146..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 615 AA; 66148 MW; A2FE489B365A4F62 CRC64;
MVSGPLALRW YAWAGRGDMG PDMELPSHSK QLLLQLNQQR TKGFLCDVII MVENSIFRAH
KNVLAASSIY FKSLVLHDNL INLDTDMVSS TVFQQILDFI YTGKLLPSDQ PAEPNFSTLL
TAASYLQLPE LAALCRRKLK RAGKPFGSGR AGAAGMGRPP RSQRLSTASV IQARYQGLVD
GHKGAHAPQE LSQAKGSDDE LFLGGSNQEG VQGLGRAICP AGGETGLGGC SSSTSGSSGG
CEQELGLDLS KKSPPLPPAT PGPHLTPDDP AQLSDSQHGS PPSASAPPVA NSASYSELGG
TPDEPMDLEG AEDNHLSLLE VPGGQPRKSL RHSTRKKEWG KKEPVAGSPF ERREVGPKGP
CPGEEGEGVG DRVPNGILAG GAGPSGPYGE PPYPCKEEEE NGKDASEDSA QSGSEGGSGH
ASAHYVYRQE GYETVSYGDN LYVCIPCAKG FPSSEQLNAH VETHTEEELF IKEEGAYETG
SGGAEEEAED LSAPSAAYAA EPRPFKCSVC EKTYKDPATL RQHEKTHWLT RPFPCNICGK
MFTQRGTMTR HMRSHLGLKP FACDECGMRF TRQYRLTEHM RVHSGEKPYE CQLCGGKFTQ
QRNLISHLRM HTSPS
//
