ID A0A2K5DGX8_AOTNA Unreviewed; 1365 AA.
AC A0A2K5DGX8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Espin {ECO:0000313|Ensembl:ENSANAP00000020240.1};
GN Name=ESPN {ECO:0000313|Ensembl:ENSANAP00000020240.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000020240.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000020240.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, stereocilium
CC {ECO:0000256|ARBA:ARBA00004645}.
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DR STRING; 37293.ENSANAP00000020240; -.
DR Ensembl; ENSANAT00000038115.1; ENSANAP00000020240.1; ENSANAG00000027903.1.
DR GeneTree; ENSGT00940000160408; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0032420; C:stereocilium; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR24153; ESPIN; 1.
DR PANTHER; PTHR24153:SF14; ESPIN ISOFORM X1; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF02205; WH2; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM00248; ANK; 8.
DR SMART; SM00246; WH2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 6.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS51082; WH2; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hearing {ECO:0000256|ARBA:ARBA00022740};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 69..93
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 103..127
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 171..193
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 205..227
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 239..268
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 271..303
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 651..668
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 347..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 663..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1098..1122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1256..1334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 811..847
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 349..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..463
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..507
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..622
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..651
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..708
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1256..1284
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1297..1322
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1365 AA; 147679 MW; 29861D434A974809 CRC64;
MALEQALQAA RQGELDVLRS LHAAGLLGPS LSDPLDALPV HHAARAGKLH CLRFLVEEAA
LPAAARARNG ATPAHDAAAT GHLACLQWLL SQGGCRVQDK DNSGATVLHL AARFGHPEVV
NWLLHHGGGD PTAATDMGAL PIHYAAAKGD FPSLRLLIGH YPEGVNAQTK NGATPLYLAC
QEGHLEVTQY LVQECGADPH ARAHDGMTPL HAAAQMGHSP VIVWLVSCTD VSLSEQDKDG
ATAMHFAASR GHTKVLSWLL LHGGEISADL WGGTPLHDAA ENGELECCQI LVVNGAELDV
RDRDGYTAAD LSDFNGHSHC TRYLRTVENL SVEHRVLSRD PSAELEAKQL DSGMSSPNTT
VSVQPLNFDL SSPASTLSNY DSCSSSHSSI KGQRPPRRLS SARAADIQSY MDMLNPELGL
PRGTIGKPTP PPPPPSFPRP PTPRHPTAAT PPPGYPAPKP PVGPQAADIY TQTKNKLRHV
ETEALKKEPS SCDSHDGLRR QDSGRKPRAF SKQPSTGDYY RQLGRGPGET LAARPGMAHS
EEVRARQPAP TGCWRPGPAA RGSLEGPSAP PQAALLPGNH VPNGCAADPK ASRELPPPPP
PPPPPLPEAA SSLPPAPPLP LEGAGPGCGQ RRSSSSTGST KSFNMMSPTG DNSELLAEIK
AGKSLKPTPQ SKGLTTVFSG SGQPASQPDS TLPPVSPTPS PARSPTPPAA GFQPLLNGSL
VPVPPATPAP GVQLDVEALI PTHDEQGRPI PEWKRQVMVR KLQLKMQEEE EQRRKLTAAS
SCCYPREGWR YSSEHNAILG PFGELMTEAD ILRIEQQIEN LQVLHKAKKL EERLEQLELE
LEQLLPVSAA LSAPRFTVDP RRMQGRAASL PAWCSKISTL LKSMATLLAT LGGRPAHLAE
LLTADTGQPL APLPDAPWRP GPQCLGRSHS LSWCREAVAR EILECGVSVK HLRATYELRA
RGAAPALCPP PAPGREPVLE EDYVAAGSSQ AQRGRCRCAA AAAAAHGPLA DWEPLGTLGP
PEAQDRQAAL PEPEELARRP PLCTELRGVQ DYLDLRKERI VYLFLEHWRR WAFRGPGRRA
QARLRRLLPR VVAAGVGPGL EATDATDDPR PPASNGVARG PDERLRQLLR QRQAVGKLLG
HWRSLLRRVP ASPGLAHGLY WPQHFLPPLD GGAPPNYDSL TLDLFMLGYF QLLEMGLSRE
ERKFRHLLCY EMFDRLGSHP WERIRLFHRV VLEEVEAGRR SWSDGFEDLR HRFFGDGLEA
EPAPEEQVKK KEEEEKEQER TEEAAPVQTG DPPKGQPEAP AAAPQPPPPP AAPPPTSDFP
GSEGPPEDPL ELVSEMGEFS NEDICRYIDR SFSFWKEKEA ELFDI
//
