ID   A0A2K5DHB6_AOTNA        Unreviewed;       955 AA.
AC   A0A2K5DHB6;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Diaphanous related formin 2 {ECO:0000313|Ensembl:ENSANAP00000020324.1};
GN   Name=DIAPH2 {ECO:0000313|Ensembl:ENSANAP00000020324.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000020324.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000020324.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the formin homology family. Diaphanous
CC       subfamily. {ECO:0000256|ARBA:ARBA00008214}.
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DR   AlphaFoldDB; A0A2K5DHB6; -.
DR   Ensembl; ENSANAT00000038200.1; ENSANAP00000020324.1; ENSANAG00000027935.1.
DR   GeneTree; ENSGT00940000157822; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR   Gene3D; 6.10.30.30; -; 1.
DR   Gene3D; 1.10.20.40; Formin, diaphanous GTPase-binding domain; 1.
DR   Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR   Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR044933; DIA_GBD_sf.
DR   InterPro; IPR015425; FH2_Formin.
DR   InterPro; IPR042201; FH2_Formin_sf.
DR   InterPro; IPR010472; FH3_dom.
DR   InterPro; IPR014768; GBD/FH3_dom.
DR   InterPro; IPR010473; GTPase-bd.
DR   PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR   PANTHER; PTHR45691:SF3; PROTEIN DIAPHANOUS HOMOLOG 2; 1.
DR   Pfam; PF06367; Drf_FH3; 1.
DR   Pfam; PF06371; Drf_GBD; 1.
DR   Pfam; PF02181; FH2; 1.
DR   PRINTS; PR01217; PRICHEXTENSN.
DR   SMART; SM01139; Drf_FH3; 1.
DR   SMART; SM01140; Drf_GBD; 1.
DR   SMART; SM00498; FH2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR   PROSITE; PS51444; FH2; 1.
DR   PROSITE; PS51232; GBD_FH3; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT   DOMAIN          87..460
FT                   /note="GBD/FH3"
FT                   /evidence="ECO:0000259|PROSITE:PS51232"
FT   DOMAIN          623..955
FT                   /note="FH2"
FT                   /evidence="ECO:0000259|PROSITE:PS51444"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          530..611
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          199..226
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          377..404
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        29..60
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        542..609
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   955 AA;  108311 MW;  F6CC6B8AE5952F26 CRC64;
     MEQPGAAASG AGGGSEEPGG GRSNKRSAGN RAANEEETKN KPKLRDRITS FRKSTVKKEK
     PLIQHPIDSQ VAMSEFPAAQ PLYDERSLNL SEKEVLDLFE KMMEDMNLNE EKKAPLRNKD
     FTTKREMVVQ YISATAKSIV GSKVTGGLKN SKHECTLSSQ EYVHELRSGI SDEKLLNCLE
     SLRVSLTSNP VSWVNNFGHE GLGLLLDELE KLLDKKQQEN IDKKNQYKLI QCLKAFMNNK
     FGLQRILGDE RSLLLLARAI DPKQPNMMTE IVKILSAICI VGEENILDKL LGAITTAAER
     NNRERFSPIV EGLENQEALQ LQVACMQFIN ALVTSPYELD FRIHLRNEFL RSGLKTMLPD
     LKEKENDELD IQLKVFDENK EDDLTELSHR LNDIRAEMDD MNEVYHLLYN MLKDTAAENY
     FLSILQHFLL IRNDYYIRPQ YYKIIEECVS QIVLHCSGMD PDFKYRQRLD IDFTHLIDSC
     VNKAKVEESE QKAAEFSKKF DEEFTARQEA QAELQKRDEK IKELEAEIQQ LRTQAQVPSS
     SSRIPGPPPP PPLPGAGPPP PPPPPPLPGG APPPPPPPPP LPGMAGIPPP PPLLFGGPPP
     PPPLGGIPRP PGLSVDLPYG MKQKKIYKPE VSMKRINWSK VEPTELSENC FWLKVKEDKF
     ENPDLFAKLA LNFATQIKVQ KNAETLEEKK TVPTKKKVKE LRILDPKTAQ NLSIFLGSYR
     MPYEEIRNMI LEVNEDMLSE ALIQNLVKHL PEQKILNELA ELKDEYDDLC EPEQFGVVMS
     SVKMLQPRLS SILFKLTFEE HVNNIKPSII AVTLACEELK KSESFNRLLE LVLLVGNYMN
     SGSRNAQSLG FKINFLCKIR DTKSADQKTT LLHFIADICE EKYRDILKFP EELEHVESAS
     KVSAQILKSN LASMEQQIVL LERDIKKFPQ AESQHDKFVE KMTISFIYLS ILSSY
//