ID A0A2K5DHM8_AOTNA Unreviewed; 1687 AA.
AC A0A2K5DHM8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Kinesin family member 1B {ECO:0000313|Ensembl:ENSANAP00000020443.1};
GN Name=KIF1B {ECO:0000313|Ensembl:ENSANAP00000020443.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000020443.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000020443.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR Ensembl; ENSANAT00000038321.1; ENSANAP00000020443.1; ENSANAG00000027958.1.
DR GeneTree; ENSGT00940000157445; -.
DR OMA; IKITICH; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd22727; FHA_KIF1B; 1.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR CDD; cd01233; PH_KIFIA_KIFIB; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR049780; PH_KIFIA_KIFIB.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF2; KINESIN-LIKE PROTEIN KIF1A ISOFORM X1; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 5..348
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 510..566
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 1572..1670
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1421..1441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1489..1531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 629..685
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1421..1439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 97..104
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1687 AA; 190067 MW; 240944C9B49902C0 CRC64;
MSGASVKVAV RVRPFNSRET SKESKCIIQM QGNSTSIINP KNPKEAPKSF SFDYSYWSHT
SPEDPCFASQ NRVYNDIGKE MLLHAFEGYN VCIFAYGQTG AGKSYTMMGK QEESQAGIIP
QLCEELFEKI NDNCNEEMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED
LSKLAVTSYT DIADLMDAGN KARTVAATNM NETSSRSHAV FTIVFTQKKH DNETNLSTEK
VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEVSK KKKKTDFIPY
RDSVLTWLLR ENLGGNSRTA MVAALSPADI NYDETLSTLR YADRAKQIKC NAVINEDPNA
KLVRELKEEV TRLKDLLRAQ GLGDIIDTSM GSLTSSPSSC SLNSQVGLTS VTSIQERIMS
TPGGEEAIER LKESEKIIAE LNETWEEKLR KTEAIRMERE ALLAEMGVAI REDGGTLGVF
SPKKTPHLVN LNEDPLMSEC LLYYIKDGIT RVGQADAERR QDIVLSGAHI KEEHCIFRSE
RSNSGEVIVT LEPCERSETY VNGKRVSQPV QLRSGNRIIM GKNHVFRFNH PEQARAEREK
TPSAETPSEP VDWTFAQREL LEKQGIDMKQ EMEKRLQEME ILYKKEKEEA DLLLEQQRLD
YESKLQALQK QVETRSLAAE TTEEEEEEEE VSWTQHEFEL AQWAFRKWKS HQFTSLRDLL
WGNAVYLKEA NAISVELKKK VQFQFVLLTD TLYSPLPPEL LPTEMEKTHE DRPFPRTVVA
VEVQDLKNGA THYWSLEKLK QRLDLMREMY DRAGEMASSA QDESETTVTG SDPFYDRFHW
FKLVGRAFVY LSNLLYPVPL IHRVAIVSEK GEVRGFLRVA VQAIAADEEA PDYGSGIRQS
GTAKISFDNE CFNQSDFSSV AMTRSGLSLE ELRIVEGQGQ SSEVISPPEE INRMNDLDLK
SSTLLDGKMV MEGFSEEIGN HLKLGSAFTF RVTVLQASGI LPEYADIFCQ FNFLHRHDEA
FSTEPLKNNG RGSPLGFYHV QNIAVEVTES FVDYIKTKPI VFEVFGHYQQ HPLHLQGQEL
NSPPQPCRRF FPPPMPLSKP VPATKLNTMS KTSLGQSMSK YDLLVWFEIS ELEPTGEYIP
AVVDHTAGLP CQGTFLLHQG IQRRITVTII HEKGSELHWK DVRELVVGRI RNKPEVDEAA
VDAILSLNII SAKYLKSSHN SSRTFYRFEA VWDSSLHNSL LLNRVTPYGE KIYMTLSAYL
ELDHCIQPAV ITKDVCMVFY SRDAKISPPR SLRSLFGSGY SKSPDSNRVT GIYELSLCKM
ADTGSPGMQR RRRKVLDTSV AYVRGEENLA GWRPRGDSLI LEHQWELEKL ELLHEVEKTR
HFLLLRERLG DSIPKSLSDS LSPSLSSGTL STSTSISSQI STTTFESAIT PSESSGYDSA
DIESLVDREK ELATKCLQLL THTFNKEFSQ VHGSISDCKL SDISPIGRDP SESSFSSATL
TPSSTCPSLV DSRSNSLDQK TPEANSRASS PCPEFEQFQI VPAVETPYLA RAGKNEFLNL
VPDIEEIRPG SVVSKKGYLH FKEPLYSNWA KHFVIVRRPY VFIYNSDKDP VERGIINLST
AQVEYSEDQQ AMVKTPNTFA VCTKHRGVLL QALNDKDMND WLYAFNPLLA GTIRSKLSRR
CPSQPKY
//
