ID A0A2K5DHN7_AOTNA Unreviewed; 911 AA.
AC A0A2K5DHN7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=P53-induced death domain protein 1 {ECO:0000313|Ensembl:ENSANAP00000020500.1};
GN Name=PIDD1 {ECO:0000313|Ensembl:ENSANAP00000020500.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000020500.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000020500.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5DHN7; -.
DR STRING; 37293.ENSANAP00000020500; -.
DR Ensembl; ENSANAT00000038378.1; ENSANAP00000020500.1; ENSANAG00000028026.1.
DR GeneTree; ENSGT00940000161780; -.
DR OMA; HRDNLGA; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:1905369; C:endopeptidase complex; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0004175; F:endopeptidase activity; IEA:Ensembl.
DR GO; GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; IEA:Ensembl.
DR GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0016540; P:protein autoprocessing; IEA:Ensembl.
DR GO; GO:0043122; P:regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR CDD; cd08779; Death_PIDD; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR019502; Peptidase_S68_pidd.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF1; ZGC:77287; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF10461; Peptidase_S68; 1.
DR Pfam; PF00791; ZU5; 2.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00364; LRR_BAC; 6.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 323..455
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 456..597
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 789..874
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 885..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 445
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT ACT_SITE 447
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT ACT_SITE 587
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT ACT_SITE 589
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT SITE 446..447
FT /note="Cleavage; by autolysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-2"
FT SITE 588..589
FT /note="Cleavage; by autolysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-2"
SQ SEQUENCE 911 AA; 99740 MW; 38C3DA07CACA3B2D CRC64;
MSAAVEGPEL EAVAPAAEDA SEAVDAASRA LPFLGGNRLS LDLSPGGCHR LLHLCVQQPL
QLLQVEFLRL STHEEPQLLE ATLARVPRSL SRLRSLVLTG GQRRDTLGAC LRGALTALPA
GLSGLAHLAH LDLSFNSLET LPACVLQMRG LGALLLSHNY LSKLPEALGA LPALTFLAVT
HNRLQTLPPA LGALSTLQRL DLSQNLLDTL PPEIGGLGNL RELNLASNRL QSLPASLAGL
RSLRLLVLHS NLLASVPASL AHLPLLTRLD LRDNRLRDLP AELLDAPFVR LQGNPLGEAS
PEAPSSPGAA FVPEMPRLFL TSDLDSFPVT PGGCSVTLAC GVRLLFPAGA TITPITIRYR
LLLPEPGLVP LGPHDALLSR VLELQPHGVA FQQDVGLWLL FTPPRAWRCR EVVVRTRNDS
SWSDLETFLE EEAPKRLWAH CQVPHFSWFL VVSRPISNAC LVPPEGTLLC SSGHPGVKVI
FPAGATEEPR RVSMQVVRMA GRELRALLGE PEATVSPLLC LSQSGPPNFL RPVTVQLPLP
SGVTGLSLDR SCLHLLYWAP PAATWDDITA QVVLELTHLY ARFQVTHFSW YWLWYTTKNC
VGGLARKAWE RLRLHRVNLI ALQRRRDPEQ VLLQCLPRNK VDATLRRLLE RYRGPEPSDT
VEMFEGEEFF AAFERGIDVD ADRPDCVEGR ICFVFYSHLK NVKEVYVTTA LDREAQAVRG
QVSFYRGAVP VQVPEEAEAA RQRKGADALW MATLPIKLPR LRGSEGPRRG AGLSLAPLNL
GDAETGFLTQ SNLLTVAGRL GPDWPAVALH LGVSYRELQR IRHEFRDDLD GQIRHMLFSW
AERQAGQPGA VGLLVQALEQ SDRQDVAEEV RAVLELGRCK YQDSIQRTGL APKDPEGPGS
SAPQPSEPAQ A
//
