ID   A0A2K5DKR0_AOTNA        Unreviewed;       380 AA.
AC   A0A2K5DKR0;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=G protein subunit alpha 12 {ECO:0000313|Ensembl:ENSANAP00000021561.1};
GN   Name=GNA12 {ECO:0000313|Ensembl:ENSANAP00000021561.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000021561.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000021561.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the G-alpha family. G(12) subfamily.
CC       {ECO:0000256|ARBA:ARBA00010405}.
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DR   AlphaFoldDB; A0A2K5DKR0; -.
DR   STRING; 37293.ENSANAP00000021561; -.
DR   Ensembl; ENSANAT00000039449.1; ENSANAP00000021561.1; ENSANAG00000028565.1.
DR   GeneTree; ENSGT00940000157636; -.
DR   OMA; GISEHIF; -.
DR   OrthoDB; 2897309at2759; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0016328; C:lateral plasma membrane; IEA:Ensembl.
DR   GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR   GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0051721; F:protein phosphatase 2A binding; IEA:Ensembl.
DR   GO; GO:0019888; F:protein phosphatase regulator activity; IEA:Ensembl.
DR   GO; GO:0030154; P:cell differentiation; IEA:Ensembl.
DR   GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:Ensembl.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR   GO; GO:0010762; P:regulation of fibroblast migration; IEA:Ensembl.
DR   GO; GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR   GO; GO:0032006; P:regulation of TOR signaling; IEA:Ensembl.
DR   GO; GO:0007266; P:Rho protein signal transduction; IEA:Ensembl.
DR   CDD; cd00066; G-alpha; 1.
DR   Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR000469; Gprotein_alpha_12/13.
DR   InterPro; IPR001019; Gprotein_alpha_su.
DR   InterPro; IPR011025; GproteinA_insert.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR   PANTHER; PTHR10218:SF130; GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-12; 1.
DR   Pfam; PF00503; G-alpha; 1.
DR   PRINTS; PR00318; GPROTEINA.
DR   PRINTS; PR00440; GPROTEINA12.
DR   SMART; SM00275; G_alpha; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR   PROSITE; PS51882; G_ALPHA; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..35
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   380 AA;  44126 MW;  7D008CE8A01BA860 CRC64;
     MSGGADPQPL PAAGRGRRAR ERRAGGGARD AEREARRRSR DIDALLARER RAVRRLVKIL
     LLGAGESGKS TFLKQMRIIH GREFDQKALL EFRDTIFDNI LKGSRVLVDA RDKLGIPWQY
     SENEKHGMFL MAFENKAGLP VEPATFQLYV PALSALWRDS GIREAFSRRS EFQLGESVKY
     FLDNLDRIGQ LNYFPSKQDI LLARKATKGI VEHDFVIKKI PFKMVDVGGQ RSQRQKWFQC
     FDGITSILFM VSSSEYDQVL MEDRRTNRLV ESMNIFETIV NNKLFFNVSI ILFLNKMDLL
     VEKVKTVSIK KHFPDFRGDP HRLEDVQRYL VQCFDRKRRN RSKPLFHHFT TAIDTENVRF
     VFHAVKDTIL QENLKDIMLQ
//