ID A0A2K5DLQ1_AOTNA Unreviewed; 747 AA.
AC A0A2K5DLQ1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Myotubularin-related protein 12 {ECO:0000256|ARBA:ARBA00018495};
DE AltName: Full=Inactive phosphatidylinositol 3-phosphatase 12 {ECO:0000256|ARBA:ARBA00033343};
GN Name=MTMR12 {ECO:0000313|Ensembl:ENSANAP00000021900.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000021900.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000021900.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere
CC {ECO:0000256|ARBA:ARBA00004204}. Sarcoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004369}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_012315357.1; XM_012459934.1.
DR AlphaFoldDB; A0A2K5DLQ1; -.
DR Ensembl; ENSANAT00000039791.1; ENSANAP00000021900.1; ENSANAG00000028689.1.
DR GeneID; 105722456; -.
DR CTD; 54545; -.
DR GeneTree; ENSGT00940000160263; -.
DR OrthoDB; 5474662at2759; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell.
DR GO; GO:0016529; C:sarcoplasmic reticulum; IEA:UniProtKB-SubCell.
DR CDD; cd14594; PTP-MTMR12; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR022587; MTMR12-like_C.
DR InterPro; IPR030576; MTMR12_PTP.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF37; MYOTUBULARIN-RELATED PROTEIN 12; 1.
DR Pfam; PF12578; 3-PAP; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951}.
FT DOMAIN 205..643
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
SQ SEQUENCE 747 AA; 86271 MW; D07D1567E4704386 CRC64;
MLGKGVVGGG GGTKAPKPSF VSYVRPEEIH TNEKEVTEKE VTLHLLPGEQ VLCEASTVLK
YVQEDSSQHG VYGRLVCTDF KIAFLGDDES ALDNDETQFK NKVIGENDIT LHCVDQIYGV
FDEKKKTLFG QLKKYPEKLI IHCKDLRVFQ FCLRYTKEEE VKRIVSGIIH HTQAPKLLKR
LFLFSYATAA QNNIVTDPKN HTVMFDTLKD WCWELERTKG NMKYKAVSVN EGYEVCERLP
AYFVIPTPLP EENVQHFQGH GIPIWCWSCH NGSALLKMSA LPKEQDDGIL QIQKSFLDRI
YKTIHRPPYE IVKTEDLSSN FLSLQEIQTA YAKFKQLFLI DNSTEFWDTD IKWFSLLESS
SWLDIIRRCL KKAIEITECM EAQNMNVLLL EENASDLCCL ISSLVQLMMD PHCRTRIGFQ
SLIQKEWVMG GHCFLDRCNH LRQNDKEEVP VFLLFLDCVW QLVHQHPPAF EFTETYLTVL
SDSLYIPIFS TFFFNSPHQK DTNMGRDGQK TQSKPLNLLT VWDWSVQFEP KAQTLLKNPL
YVEKPKLDKG QRKGMRFKHQ RQLSLPLTQS KSSPKRGFFR EETDHLIKNL LGKRISKLIN
SSDELQDNFR EFYDSWHSKP TDYHGLLLPH IEGPEIKVWA QRYLRWIPEA QILGGGRVAT
MSKLLEMMEE VQSLQEKIDE RHYSQQAPQA EAPRLLRNSA RLSSLFPFAL LQRHSSKPVL
PTSGWKALGD EGDLAKQEDE FVDLGDI
//
