ID A0A2K5DMF2_AOTNA Unreviewed; 727 AA.
AC A0A2K5DMF2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Prolyl endopeptidase {ECO:0000256|RuleBase:RU368024};
DE EC=3.4.21.- {ECO:0000256|RuleBase:RU368024};
GN Name=PREPL {ECO:0000313|Ensembl:ENSANAP00000022138.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000022138.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000022138.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC {ECO:0000256|ARBA:ARBA00004601}.
CC -!- SIMILARITY: Belongs to the peptidase S9A family.
CC {ECO:0000256|ARBA:ARBA00005228, ECO:0000256|RuleBase:RU368024}.
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DR RefSeq; XP_012306012.1; XM_012450589.1.
DR AlphaFoldDB; A0A2K5DMF2; -.
DR STRING; 37293.ENSANAP00000022138; -.
DR Ensembl; ENSANAT00000040031.1; ENSANAP00000022138.1; ENSANAG00000028709.1.
DR GeneID; 105716057; -.
DR CTD; 9581; -.
DR GeneTree; ENSGT00530000063426; -.
DR OrthoDB; 318259at2759; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005802; C:trans-Golgi network; IEA:Ensembl.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0043001; P:Golgi to plasma membrane protein transport; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:2000300; P:regulation of synaptic vesicle exocytosis; IEA:Ensembl.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:Ensembl.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.130.10.120; Prolyl oligopeptidase, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR023302; Pept_S9A_N.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002470; Peptidase_S9A.
DR PANTHER; PTHR11757:SF19; PROLYL ENDOPEPTIDASE-LIKE; 1.
DR PANTHER; PTHR11757; PROTEASE FAMILY S9A OLIGOPEPTIDASE; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR Pfam; PF02897; Peptidase_S9_N; 1.
DR PRINTS; PR00862; PROLIGOPTASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU368024};
KW Protease {ECO:0000256|RuleBase:RU368024};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Serine protease {ECO:0000256|RuleBase:RU368024}.
FT DOMAIN 108..426
FT /note="Peptidase S9A N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02897"
FT DOMAIN 490..704
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 727 AA; 84027 MW; 86A279E7D8FC8990 CRC64;
MQQKTKLFLQ VLKYSIPHLG KCMQKQPLNH CNFADHYCNR IKLKKYHLTK YLQNKPKISE
LARNIPSRSF SCKDLQPVKQ ENKKPLPENM DAFEKVRTRL ETQPQEEYEI INVEVKHGGF
VYYQEGCCLV RSKDEEADND NYEVLFNLEE LKLDQPFIDC IRVAPDEKYV AAKIRTEDSE
ASTCVVIKLS DQPVMEASFP NVSSFEWVKD EEDEDVLFYT FQRNLRCNDV YRATFGDNKR
NERFYTEKDP SYFVFLYLTK DSRFLTMNIM NKMTSEVWLI DGLSPWDPPV LIQKRIHGVL
YYVEHRDDEL YILTNVGEPT EFKLMRTAAD TPAIMNWDLF FTMKRNTKVI DLDMFKDHCV
LFLKHSNLLY VNVIGLADDS VRSLKLPPWA CGFIMDTNSD PKNCPFQLCS PIRPPKYYTY
KFAEGKLFEE TGHEDPITKT SRVLRLEAKS KDGKLVPMTI FHKTDSEDLQ KKPLLVHVYG
AYGMDLKMNF RPERRVLVDD GWILAYCHVR GGGELGLQWH ADGRLTKKLN GLADLEACIK
TLHGQGFSQP SLTTLTAFSA GGVLAGALCN SNPELLRAVT LEAPFLDVLN TMMDTTLPLT
LEELEEWGNP SSDEKHKNYI KRYCPYQNIK PQHYPSIHIT AYENDERVPL KGVVSYTEKL
KEAIMEHTKD TGEGYQAPNI ILDIQPGGNH VIEDSHKKIT AQIKFLYEEL GLDSTSVFED
LKKYLKF
//