ID A0A2K5DMY4_AOTNA Unreviewed; 1870 AA.
AC A0A2K5DMY4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Ankyrin 2 {ECO:0000313|Ensembl:ENSANAP00000022329.1};
GN Name=ANK2 {ECO:0000313|Ensembl:ENSANAP00000022329.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000022329.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000022329.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR Ensembl; ENSANAT00000040224.1; ENSANAP00000022329.1; ENSANAG00000028204.1.
DR GeneTree; ENSGT00940000155279; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08804; Death_ank2; 1.
DR Gene3D; 2.60.220.30; -; 3.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF49; ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING 1B; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 6.
DR Pfam; PF13637; Ank_4; 2.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 3.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 23.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 20.
DR PROSITE; PS50088; ANK_REPEAT; 20.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 38..70
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 71..103
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 104..136
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 207..239
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 240..272
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 273..305
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 306..338
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 339..371
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 372..404
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 405..437
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 438..470
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 471..503
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 504..536
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 537..569
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 570..602
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 603..635
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 636..668
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 669..701
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 702..734
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 735..767
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 964..1152
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1154..1300
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1470..1554
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1624..1653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1676..1756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1813..1834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1849..1870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1638..1653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1676..1701
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1710..1724
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1730..1744
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1870 AA; 205528 MW; 2B5C893273B5B1B8 CRC64;
ITTSDSNASF LRAARAGNLD KVVEYLKGGI DINTCNQNGL NALHLAAKEG HVGLVQELLG
RGSSVDSATK KGNTALHIAS LAGQAEVVKV LVKEGANINA QSQNGFTPLY MAAQENHIDV
VKYLLENGAN QSTATEDGFT PLAVALQQGH NQAVAILLEN DTKGKVRLPA LHIAARKDDT
KSAALLLQND HNADVQSKMM VNRTTESGFT PLHIAAHYGN VNVATLLLNR GAAVDFTARN
GITPLHVASK RGNTNMVKLL LDRGGQIDAK TRDGLTPLHC AARSGHDQVV ELLLERGAPL
LARTKNGLSP LHMAAQGDHV ECVKHLLQHK APVDDVTLDY LTALHVAAHC GHYRVTKLLL
DKRANPNARA LNGFTPLHIA CKKNRIKVME LLVKYGASIQ AITESGLTPI HVAAFMGHLN
IVLLLLQNGA SPDVTNIRGE TALHMAARAG QVEVVRCLLR NGALVDARAR EEQTPLHIAS
RLGKTEIVQL LLQHMAHPDA ATTNGYTPLH ISAREGQVDV ASVLLEAGAA HSLATKKGFT
PLHVAAKYGS LDVAKLLLQR RAAADSAGKN GLTPLHVAAH YDNQKVALLL LEKGASPHAT
AKNGYTPLHI AAKKNQMQIA STLLNYGAET NIVTKQGVTP LHLASQEGHT DMVTLLLDKG
ANIHMSTKSG LTSLHLAAQE DKVNVADILA KHGADQDAHT KLGYTPLIVA CHYGNVKMVN
FLLKQGANVN AKTKNGYTPL HQAAQQGHTH IINVLLQHGA KPNATTAVRQ TPLPLTTLSP
FSSLALVASL RSDSFSEPYS LNKPPGLWKT ITEKHKLNVP ETMTEVLDVS DEEGDDTMTG
DGGEYLRPED LKELGDDSLP SSQFLDGMNY LRYSLEGGRS DSLRSFSSDR SHTLSHASYL
RDSAVMDDSV VIPSHQVSAL AKEAERNSYR LSWGTENLDN VALSSSPIHS GRASPCLDRD
NSSFLVSFMV DARGGAMRGC RHNGLRIIIP PRKCTAPTRV TCRLVKRHRL ATMPPMVEGE
GLASRLIEVG PSGAQFLGKL HLPTAPPPLN EGESLVSRIL QLGPPGTKFL GPVIVEIPHF
AALRGKEREL VVLRSENGDS WKEHFCDYTE DELNEILNGM DEVLDSPEDL EKKRICRIIT
RDFPQYFAVV SRIKQDSNLI GPEGGVLSST VVPQVQAVFP EGALTKRIRV GLQAQPMHSE
LVKKILGNKA TFSPIVTLEP RRRKFHKPIT MTIPVPKASS DVMLNGFGGD APTLRLLCSI
TGGTTPAQWE DITGTTPLTF VNECVSFTTN VSARFWLIDC RQIQESVTFA SQVYREIICV
PYMAKFVVFA KSHDPIEARL RCFCMTDDKV DKTLEQQENF AEVARSRDVE VLEGKPIYVD
CFGNLVPLTK SGQHHIFSFF AFKENRLPLF VKVRDTTQEP CGRLSFMKEP KSTRGLVHQA
ICNLNITLPI YTKESESDQE QEEEDEQERI EERLAYIADH LGFSWTELAR ELDFTEEQIH
QIRIENPNSL QDQSHALLKY WLERDGKHAT DTNLIECLTK INRMDIVHLM ETNTEPLQER
ISHSYAEIEQ TITLDHSEGF SVLQEELCTA QHKQKEEQAV SKESETCDHP PIVSEEDISV
GYSTFQDGIP KTEGDSPATA LFPQTHKEQV QQDFSGNMQD LPEESSLEYQ QEYFVTSPGT
ETSETQKPTA VPSSPSKTPE EVSTPPEEER LYLQTPTSSE RGGSPIIQEP DEPSEHREES
SPRKTSLVIV ESADNQLETC ERVDEDAAFE KGDDMPEIPP ETVTEEEYID EHGHTVVKKV
TRKIIRRYVS SEGTEKEEIT VQGMPQEPVN IEEGDGYSKV IKRVVLKSDT EQSEVRQPDS
LKPIQWRGPK
//
