ID A0A2K5DN37_AOTNA Unreviewed; 1181 AA.
AC A0A2K5DN37;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Solute carrier family 12 member 2 {ECO:0000313|Ensembl:ENSANAP00000022388.1};
GN Name=SLC12A2 {ECO:0000313|Ensembl:ENSANAP00000022388.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000022388.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000022388.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A2K5DN37; -.
DR Ensembl; ENSANAT00000040284.1; ENSANAP00000022388.1; ENSANAG00000028637.1.
DR GeneTree; ENSGT00940000155742; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IEA:UniProt.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR002444; NKCC1.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF58; SOLUTE CARRIER FAMILY 12 MEMBER 2; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 1.
DR PRINTS; PR01207; NAKCLTRNSPRT.
DR PRINTS; PR01208; NAKCLTRSPRT1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 286..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 456..478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 568..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 624..644
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 680..699
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 705..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 171..222
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 259..761
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 770..1181
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 933..960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..957
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1181 AA; 128788 MW; ECF425980473173B CRC64;
QLPAWRGRAG GREPASLRRR ARDGGGVLGE GAAAGGDGLG RPLGPTPSQS RFQVDLVSEN
AGRAAAAAAA AAAAAAAGAG AGAKQTPADG KASGESGPAK SSEEAKGRFR VNFVDPAASS
SAEDSLSDVA GVGGEGPNVS FQNGGDTVLS EGSSLHSGGG GSGHHQHYYY DTHTNTYYLR
TFGHNTMDAV PRIDHYRHTA AQLGEKLLRP SLAELHDELE KEPFEDGFAN GEESTPARDA
VVTYTAESKG VVKFGWIKGV LVRCMLNIWG VMLFIRLSWI VGQAGIGLSV LVIMMATVVT
TITGLSTSAI ATNGFVRGGG AYYLISRSLG PEFGGAIGLI FAFANAVAVA MYVVGFAETV
VELLKEHSIL MIDEINDIRI IGAITVVILL GISVAGMEWE AKAQIVLLVI LLLAIGDFVI
GTFIPLESKK PKGFFGYKSE IFNENFGPDF REEETFFSVF AIFFPAATGI LAGANISGDL
ADPQSAIPKG TLLAILITTL VYVGIAVSVG SCVVRDATGN VNDTIVTELT NCTSAACKLN
FDFSSCESNP CSYGLMNNFQ VMSMVSGFAP LISAGIFSAT LSSALASLVS APKIFQALCK
DNIYPAFQMF AKGYGKNNEP LRGYILTFLI ALGFILIAEL NVIAPIISNF FLASYALINF
SVFHASLAKS PGWRPAFKYY NMWISLIGAI LCCIVMFVIN WWAALLTYVI VLGLYIYVTY
KKPDVNWGSS TQALTYLSAL QHSIRLSGVE DHVKNFRPQC LVMTGAPNSR PALLHLVHDF
TKNVGLMICG HVHMGPRRQA MKEMSIDQAK YQRWLIKNKM KAFYAPVHAD DLREGAQYLM
QAAGLGRMKP NTLVLGFKKD WLQADMRDVD MYINLFHDAF DIQYGVVVIR LKEGLDISHL
QGQEELLSSQ EKSPGTKDVV VSVEYSKISD LDTSKPLSEK PVTHKDEEED GKTPTQPLLK
KESKGPIVPL NVADQKLLEA STQFQKKQGK NTIDVWWLFD DGGLTLLIPY LLTTKKKWKD
CKIRVFIGGK INRIDHDRRA MATLLSKFRI DFSDIMVLGD INTKPKKENI VAFDEMIEPY
RLHEDDKEQD IADKMKEDEP WRITDNELEL YKTKTYRQIR LNELLKEHSS TANIIVMSLP
VARKGAVSSA LYMAWLEALS KDLPPILLVR GNHQSVLTFY S
//
