ID A0A2K5DNY9_AOTNA Unreviewed; 839 AA.
AC A0A2K5DNY9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Neuronal PAS domain protein 2 {ECO:0000313|Ensembl:ENSANAP00000022685.1};
GN Name=NPAS2 {ECO:0000313|Ensembl:ENSANAP00000022685.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000022685.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000022685.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_012333062.1; XM_012477639.1.
DR AlphaFoldDB; A0A2K5DNY9; -.
DR Ensembl; ENSANAT00000040584.1; ENSANAP00000022685.1; ENSANAG00000029045.1.
DR GeneID; 105734719; -.
DR CTD; 4862; -.
DR GeneTree; ENSGT00940000160744; -.
DR OMA; RPCRMPL; -.
DR OrthoDB; 2899615at2759; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0032922; P:circadian regulation of gene expression; IEA:InterPro.
DR CDD; cd19737; bHLH-PAS_NPAS2_PASD4; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR047230; CLOCK-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR46055; CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT; 1.
DR PANTHER; PTHR46055:SF1; NEURONAL PAS DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 27..77
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 100..163
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 278..325
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 383..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 694..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 753..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..681
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..805
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 806..820
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..839
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 839 AA; 93475 MW; C3599AA778EA4DB0 CRC64;
MHAVTPLSQE RKNCIENLMD EDEKDRAKRA SRNKSEKKRR DQFNVLIKEL SSMLPGNTRK
MDKTTVLEKV IGFLQKHNEV SAQTEICDIQ QDWKPSFLSN EEFTQLMLEA LDGFIIAVTT
DGSIIYVSDS ITPLLGHLPS DVMDQNLLNF LPEQEHSEVY KILSSHMLVT DSPSPEYLKS
DSDLEFYCHL LRGSLNPKEF PTYEYIKFVG NFRSYNNVPS PSCNGFDNTL SRPCRVPLGK
EVCFIATVRL ATPQFLKEMC IVDEPLEEFT SRHSLEWKFL FLDHRAPPII GYLPFEVLGT
SGYDYYHIDD LELLARCHQH LMQFGKGKSC CYRFLTKGQQ WIWLQTHYYI TYHQWNSKPE
FIVCTHSVVS YADVRVERRQ ELALEDPSSE ALHSSALKDK GSSLEPRQHF SALDVGASGL
NTSNSPSASS RSSHKSSHTA MSEPTSTPTK LMAEASTPAL PRPATLPQEL PVPGLSQAAT
MPAPLPSPSS CDLAQQLLPQ TILQSPPAPM AQFSAQFSMF QTIKDQLEQR TRILQANIRW
QQEELHKIQE QLCLVQDSNV QMFLQPPAVS LSFSSTQRPE QQLQQRSATV TQPQLGAGPQ
LPGQISSAQV TSQHLLRESS VISTQGPKPL RSSLMQSSGR SGSSLVSPFS STTAVLPTSL
NLTTPASTSQ DASQCQPSPD FSHDRQLRLL LSQPIQPMMP GSCDARQPSE VSRTGRQVKY
AQSQTVFQNP DAHPTNSSSA PMPVLLMGQA VLHPSFPTSQ PSPLQPAQAR QQPPQHYLQV
QAPTSLHSEQ QDSLLLSTYS QQPGTLGYPA PPPAQPQPLR PPRRVSSLSE SSGLQQPPR
//
