ID A0A2K5DPV4_AOTNA Unreviewed; 962 AA.
AC A0A2K5DPV4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Myosin XIX {ECO:0000313|Ensembl:ENSANAP00000023010.1};
GN Name=MYO19 {ECO:0000313|Ensembl:ENSANAP00000023010.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000023010.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000023010.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR RefSeq; XP_012300905.1; XM_012445482.1.
DR RefSeq; XP_012300906.1; XM_012445483.1.
DR AlphaFoldDB; A0A2K5DPV4; -.
DR STRING; 37293.ENSANAP00000023010; -.
DR Ensembl; ENSANAT00000040913.1; ENSANAP00000023010.1; ENSANAG00000029214.1.
DR GeneID; 105712460; -.
DR CTD; 80179; -.
DR GeneTree; ENSGT00940000157382; -.
DR OrthoDB; 1094820at2759; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:Ensembl.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR GO; GO:0032027; F:myosin light chain binding; IEA:Ensembl.
DR GO; GO:0060002; F:plus-end directed microfilament motor activity; IEA:Ensembl.
DR GO; GO:0034642; P:mitochondrion migration along actin filament; IEA:Ensembl.
DR GO; GO:0160040; P:mitocytosis; IEA:Ensembl.
DR GO; GO:0032465; P:regulation of cytokinesis; IEA:Ensembl.
DR GO; GO:0090140; P:regulation of mitochondrial fission; IEA:Ensembl.
DR CDD; cd14880; MYSc_Myo19; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR036035; MYSc_Myo19.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF289; UNCONVENTIONAL MYOSIN-XIX; 1.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT DOMAIN 35..758
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 602..624
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 132..139
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 962 AA; 108370 MW; EC11DC639E5ABA55 CRC64;
MLQQVNGHNL GSDGQARESL REDLQEFLGG EVLLYQLDDL TKVNPVTLET VLRCLQSRYM
ADTFYTNAGC TLVALNPFKP VPQLYSPELM REYHAAPQPQ KLKPHVFTVG EQTYRNVKSL
IEPVNQSIVV SGESGAGKTW TSRCLMNFYA VVAASPTSWE SHKIAERIEQ RILNSNPVME
AFGNACTLRN NNSSRFGKFI QLQLNRAQQM VGAAVQTYLL EKTRVVCQAF SERNFHIFYQ
ICKGASEDER LQWHLPEGAA FSWLPNPERS LEEDCFEVTR EAMLHLGIDT PTQNNIFKVL
AGLLHLGNIQ FAASEDEAQP CQPMDDAKCS VRTAASLLGL QEDVLLKTVQ IRTIRAGRQQ
QLFRKPCPRA ECDTRRDCLA KLIYARLFDW LVSVINSSIC ADTNSWTTFI GLLDVYGFES
FPDNSLEQLC INYANEKLQQ HFVAHYLRAQ QEEYAAEDLE WSFISYQDNQ PCLDLIEGSP
ISICSLINEE CRLNRPSSAA QLQTRIETAL AGSPCLGHNK LSREPGFIVV HYAGPVRYHT
GGLVEKNKDP IPPELTGLLQ QSQDPLLLGL FPTNPKEKTQ VEPSGQSRAP VLTVVSKFKA
SLEQLLQVLH STTPHYIRCI KPNSQSQAQT FVQEEVLSQL EACGLVETIH ISAAGFPIRV
SHQNFVERYK LLRRLRPCTS SGPHSPYPAK GLPEWCPHAK EATLEPLLQD ILHTLPVLTQ
TKATPGDLAE AMPTPVHCGR TKVFMTDSML ELLECGRDQV LEQCARCIQS GWRRHRQRKQ
ERQRQATILI QAAIRSWLTR KRIQRLHAAA TVIKRTWQKW RIRMACLAAE ELDDVEEKHL
SQAPGSLSTS PLQTRLLEAV IRLWPLGLVL TNTAMGVGNF QRKLVVWACL QLPRGSPSSY
TVQTAQQDQA GVTSIRAMPQ GSIKFHCKKS PLRYADICPE PSPYSVTGFN QILLERHRLI
HM
//
