ID   A0A2K5DQ10_AOTNA        Unreviewed;       775 AA.
AC   A0A2K5DQ10;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 {ECO:0000313|Ensembl:ENSANAP00000023056.1};
GN   Name=ASAP3 {ECO:0000313|Ensembl:ENSANAP00000023056.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000023056.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000023056.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_012295631.1; XM_012440208.1.
DR   AlphaFoldDB; A0A2K5DQ10; -.
DR   Ensembl; ENSANAT00000040959.1; ENSANAP00000023056.1; ENSANAG00000029202.1.
DR   GeneID; 105708611; -.
DR   CTD; 55616; -.
DR   GeneTree; ENSGT00940000161085; -.
DR   OrthoDB; 1449795at2759; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd17900; ArfGap_ASAP3; 1.
DR   CDD; cd13251; PH_ASAP; 1.
DR   Gene3D; 1.25.40.950; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR043593; ASAP.
DR   InterPro; IPR047006; ASAP3_ArfGap.
DR   InterPro; IPR004148; BAR_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR037844; PH_ASAP.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR45854:SF1; ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR   PANTHER; PTHR45854; ASAP FAMILY MEMBER; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF16746; BAR_3; 1.
DR   Pfam; PF00169; PH; 1.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00248; ANK; 2.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW   ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   DOMAIN          171..263
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          295..420
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50115"
FT   REPEAT          490..522
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REGION          146..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          614..775
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        646..680
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        700..728
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        761..775
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   775 AA;  84824 MW;  4C9F71C64655058D CRC64;
     MKGQLRDGRQ DSKKQLEKAW KDYEAKMAKV EKERDRARVT GGIHGEVAQD TQRERRIFQL
     HMCEYLLKAG ESQMKQGPDF LQSLIKFFHA QHNFFHDGWK AAQSLSPFIE KLAASVHALH
     QAQEEELQKL TQLRDSLRGT LQLDSREEHL SRKNSGGGYS IHQHQGNKQF GTEKVGFLYK
     KSDGIRRVWQ KRKCGVKYGC LTISHSTINR PPVKLTLLTC QVRPNPEEKK CFDLVTHNRT
     YHFHAEDEHE CEAWVSVLQN SKDEALSSAF LGEPSGGPGS WGAAGQDGEP QDLTKLLIAE
     VKSRPGNSQC CDCGAADPTW LSTNLGVLTC IQCSGVHREL GVRFSRMQSL TLDLLGPSEL
     LLALNIGNTS FNEVMEAQLP SHGGPKPSAE SDMGTRRDYI VAKYVEHRFA RRCTPEPQRL
     WTAICNRDLL SVLEAFANGQ DFGQPLPGPD AQAPEELALH LAVKVANQAS LPLVDFIIQN
     GGHLDARAAD GSTAVHYAAL YNQPDCIKLL LKGRALVGTV NEAGETALDI ARKKQHKECE
     ELLEQAQAGT LAFPLHVDYS WGISTEPGSE SEEDEDEKRC LLKPPAQAHW ASGRLDISNK
     TYETIASLGA ATLQGESEDC PPPLPIKNSS RTMVQGCARR ASGDRSEGPS LSSDASEAPE
     SLGSPASSSS SSSLMSPTDP GGPSQAPPSS EDGLREPPGT SRPSLTSGTT PSEMYLPVRF
     SSESTRSYRR GARSLEDGSS ARQPLPRRNM PVGFTEGDGS RTGTLPASSM QLLQD
//