ID A0A2K5DQ63_AOTNA Unreviewed; 875 AA.
AC A0A2K5DQ63;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 {ECO:0000313|Ensembl:ENSANAP00000023088.1};
GN Name=ASAP3 {ECO:0000313|Ensembl:ENSANAP00000023088.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000023088.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000023088.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5DQ63; -.
DR Ensembl; ENSANAT00000040991.1; ENSANAP00000023088.1; ENSANAG00000029202.1.
DR GeneTree; ENSGT00940000161085; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd17900; ArfGap_ASAP3; 1.
DR CDD; cd13251; PH_ASAP; 1.
DR Gene3D; 1.25.40.950; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR043593; ASAP.
DR InterPro; IPR047006; ASAP3_ArfGap.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037844; PH_ASAP.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45854:SF1; ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR45854; ASAP FAMILY MEMBER; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 271..363
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 395..520
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 590..622
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 245..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 800..828
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..875
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 875 AA; 95944 MW; 2DC59C5A85A2744E CRC64;
TFIEHLLCAR HEDLSSRDFG NLFGNYQAIL QRIKKAVRAI HSSGLGHVEN EEQYREAVES
LGNSHLSQNS HELSTGFLNL AVFTREVAAL FKNLVQNLNN IVSFPLDSLM KGQLRDGRQF
FLSLGFRAKV EKERDRARVT GGIHGEVAQD TQRERRIFQL HMCEYLLKAG ESQMKQGPDF
LQSLIKFFHA QHNFFHDGWK AAQSLSPFIE KLAASVHALH QAQEEELQKL TQLRDSLRGT
LQLDSREEHL SRKNSGGGYS IHQHQGNKQF GTEKVGFLYK KSDGIRRVWQ KRKCGVKYGC
LTISHSTINR PPVKLTLLTC QVRPNPEEKK CFDLVTHNRT YHFHAEDEHE CEAWVSVLQN
SKDEALSSAF LGEPSGGPGS WGAAGQDGEP QDLTKLLIAE VKSRPGNSQC CDCGAADPTW
LSTNLGVLTC IQCSGVHREL GVRFSRMQSL TLDLLGPSEL LLALNIGNTS FNEVMEAQLP
SHGGPKPSAE SDMGTRRDYI VAKYVEHRFA RRCTPEPQRL WTAICNRDLL SVLEAFANGQ
DFGQPLPGPD AQAPEELALH LAVKVANQAS LPLVDFIIQN GGHLDARAAD GSTAVHYAAL
YNQPDCIKLL LKGRALVGTV NEAGETALDI ARKKQHKECE ELLEQAQAGT LAFPLHVDYS
WGISTEPGSE SEEDEDEKRC LLKPPAQAHW ASGRLDISNK TYETIASLGA ATLQGESEDC
PPPLPIKNSS RTMVQGCARR ASGDRSEGPS LSSDASEAPE SLGSPASSSS SSSLMSPTDP
GGPSQAPPSS EDGLREPPGT SRPSLTSGTT PSEMYLPVRF SSESTRSYRR GARSLEDGSS
ARQPLPRRNM PVGFTEGDGS RTGTLPASSM QLLQD
//
