ID A0A2K5DS11_AOTNA Unreviewed; 1401 AA.
AC A0A2K5DS11;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Patched 1 {ECO:0000313|Ensembl:ENSANAP00000023750.1};
GN Name=PTCH1 {ECO:0000313|Ensembl:ENSANAP00000023750.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000023750.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000023750.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR Ensembl; ENSANAT00000041663.1; ENSANAP00000023750.1; ENSANAG00000029389.1.
DR GeneTree; ENSGT00940000159011; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR004766; TM_rcpt_patched.
DR NCBIfam; TIGR00918; 2A060602; 1.
DR PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR PANTHER; PTHR46022:SF5; PROTEIN PATCHED HOMOLOG 1; 1.
DR Pfam; PF02460; Patched; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 449..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 495..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 524..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 702..719
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 739..757
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 978..999
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1005..1027
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1034..1060
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1072..1092
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1104..1129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 443..549
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1141..1185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1221..1313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1144..1159
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1167..1185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1224..1239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1298..1313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1401 AA; 157032 MW; 177CA3C1A61B2CEB CRC64;
MASAGNAAEP QDRRRRRRRR RRLYRCPGRP AGGGRRRRIG GLRRAAAPDR DYLHRPSYCD
AAFALEQISK GKATGRKAPL WLRAKFQRLL FKLGCYIQKN CGKFLVVGLL IFGAFAVGLK
AANLETNVEE LWVEVGGRVS RELNYTRQKI GEEAMFNPQL MIQTPKEEDA NVLTTEALLQ
HLDSALQASR VHVYMYNRQW KLEHLCYKSG ELITETGYMD QIIEYLYPCL IITPLDCFWE
GAKLQSGTAY LLGKPPLRWT NFDPLEFLEE LKKINYQVDS WEEMLNKAEV GHGYMDRPCL
NPADPDCPAT APNKNSTKPL DTALVLNGGC HGLSRKYMHW QEELIVGGTV KNSTGKLISA
HALQTMFQLM TPKQMYEHFK GYEYVSHINW NEDKAAAILE AWQRTYVEVV HQSVAQNSTQ
KVLSFTTTTL DDILKSFSDV SVIRVASGYL LMVLPFLALG VGVDDVFLLA HAFSETGQNK
RIPFEDRTGE CLKRTGASVA LTSISNVTAF FMAALIPIPA LRAFSLQAAV VVVFNFAMVL
LIFPAILSMD LYRREDRRLD IFCCFTSPCV SRVIQVEPQA YTDTHDSTCY SPPPPYSSHS
FAHETQITMQ STVQLRTEYD PHTHVYYTTA EPRSEISVQP VTVTQDTLSC QSPESTSSTR
DLLSQFSDSS LHCLEPPCTK WTLSSFAEKH YAPFLLKPKA KVVVIFLFLG LLGVSLYGTT
RVKDGLDLTD IVPRETREYD FIAAQFKYFS FYNMYIVTQK ADYPNIQHLL YDLHRSFSNV
KYVMLEENKQ LPKMWLHYFR DWLQGLQDAF DSDWETGKIM PNNYKNGSDD GVLAYKLLVQ
TGSRDKPIDI SQLTKQRLVD ADGIINPSAF YIYLTAWVSN DPVAYAASQA NIRPHRPEWV
HDKADYMPET RLRIPAAEPI EYAQFPFYLN GLRDTSDFVE AIEKVRTICS NYTSLGLSSY
PNGYPFLFWE QYIGLRHWLL LFISVVLACT FLVCAVFLLN PWTAGIIVMV LALMTVELFG
MMGLIGIKLS AVPVVILIAS VGIGVEFTVH VALAFLTAIG DKNRRAVLAL EHMFAPVLDG
AVSTLLGVLM LAGSEFDFIV RYFFAVLAIL TILGVLNGLV LLPVLLSFFG PYPEVSPANG
LNRLPTPSPE PPPSVVRFAV PPGPMHSGSD SSDSEYSSQT TVSGLSEELR HYEAQQGVGG
PAHQVIVEAT ENPVFAHSTV VPPESRHHQP SNPRQQPHLD SGSLPPGRQG QQPRRNPPRE
GLWPPPYRPR RDAFEISTEG HSGPSNRDRW GPRGTRSHNP RNPASTAMGS SMPGYCQPIT
TVTASASVTV AVHPPPVPAP GRNPRGGLCP GYEGYPETDH GLFEDPHVPF HVRRERRDSK
VEVIELQDVE CEERPRGSSS N
//
