ID A0A2K5DVQ7_AOTNA Unreviewed; 1036 AA.
AC A0A2K5DVQ7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=RAS p21 protein activator 1 {ECO:0000313|Ensembl:ENSANAP00000025035.1};
GN Name=RASA1 {ECO:0000313|Ensembl:ENSANAP00000025035.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000025035.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000025035.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5DVQ7; -.
DR Ensembl; ENSANAT00000042955.1; ENSANAP00000025035.1; ENSANAG00000029874.1.
DR GeneTree; ENSGT00940000155846; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd08400; C2_Ras_p21A1; 1.
DR CDD; cd13260; PH_RASA1; 1.
DR CDD; cd05391; RasGAP_p120GAP; 1.
DR CDD; cd10354; SH2_Cterm_RasGAP; 1.
DR CDD; cd10353; SH2_Nterm_RasGAP; 1.
DR CDD; cd11788; SH3_RasGAP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR035842; RasGAP_C_SH2.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR035841; RasGAP_N_SH2.
DR InterPro; IPR035652; RasGAP_SH3.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10194:SF146; RAS GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF00017; SH2; 2.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00252; SH2; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 183..274
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 281..343
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 340..430
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 463..566
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 566..679
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 737..931
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
SQ SEQUENCE 1036 AA; 114944 MW; 5EBD714D9C17DBC6 CRC64;
MMAAEAGSEE GGPVTAGAGG GGAAAGSSAY PAVCRVRIPA ALPVAAAPYP GLVETGVAGT
LGGGAALGSG FLGTGSVAGA LGGAGLTGGG TAAGVAGAAA GVAGAAAAAA GPSGDMSLTK
LLTSLPAETL GPGGVFPPLP PPPHLPPLGA GLGTVDEGDS LDGPEYEEEE VAIPLTAPPT
NQWYHGKLDR TIAEERLRQA GKSGSYLIRE SDRRPGSFVL SFLSQMNVVN HFRIIAMCGD
YYIGGRRFSS LSDLIGYYSH VSCLLKGEKL LYPVAPPEPV EDRRRVRAIL PYTKVPDTDE
ISFLKGDMFI VHNELEDGWM WVTNLRTDEQ GLIVEDLVEE VVSFISKQEA YNLLMTVGQV
CSFLVRPSDN TPGDYSLYFR TSENIQRFKI CPTPNNQFMM GGRYYNSIGD IIDHYRKEQI
VEGYYLKEPV PMQDQEQVLN DTVDGKEIYN TIRRKTKDAF YKNIVKKGYL LKKGKGKRWK
NLYFILEGSD AQLIYFESEK RATKPKGLID LSVCSVYVVH DSLFDRPNCF QIVVQHFSEE
HYIFYFAGET PEQAEDWMKA LQAFCSLRKS SPGTSNKRLR QVSSLVLHIE EAHKLPVKHF
TNPYCNIYLN SVQVAKTHAR EGQNPVWSEE FVFDDLPPDI NRFEITLSNK TKKSKDPDIL
FMRCQLSRLQ KGHATDEWFL LSSHIPLKGI EPGSLRVRAR YSMEKIMPEE EYSEFKELIL
QKELHVVYAL SHVCGQDRTL LASILLRIFL HEKLESLLLC TLNDREISME DEATTLFRAT
TLASTLMEQY MKATATQFVH HALKDSILKI MESKQSCELS PSKLEKNEDV NANLAHLLNI
LSELVEKIFM ASEILPPTLR YIYGCLQKSV QHKWPTNTTM RTRVVSGFVF LRLICPAILN
PRMFNIISDS PSPIAARTLT LVAKSVQNLA NLVEFGAKEP YMEGVNPFIK SNKHRMIMFL
DELGNVPELP DTTEHPRTDL SRDLAALHEI CVAHSDELRT LSNERGAQQH VLKKLLAITE
LLQQKQHQYT KTNDVR
//
