ID A0A2K5DX84_AOTNA Unreviewed; 366 AA.
AC A0A2K5DX84;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Apolipoprotein A-V {ECO:0000256|ARBA:ARBA00040758};
DE AltName: Full=Apolipoprotein A5 {ECO:0000256|ARBA:ARBA00042594};
GN Name=APOA5 {ECO:0000313|Ensembl:ENSANAP00000025609.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000025609.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000025609.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC {ECO:0000256|ARBA:ARBA00004601}. Late endosome
CC {ECO:0000256|ARBA:ARBA00004603}.
CC -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC {ECO:0000256|ARBA:ARBA00008788}.
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DR RefSeq; XP_012325877.1; XM_012470454.1.
DR RefSeq; XP_012325878.1; XM_012470455.1.
DR AlphaFoldDB; A0A2K5DX84; -.
DR STRING; 37293.ENSANAP00000025609; -.
DR Ensembl; ENSANAT00000043532.1; ENSANAP00000025609.1; ENSANAG00000030524.1.
DR GeneID; 105729582; -.
DR CTD; 116519; -.
DR GeneTree; ENSGT00950000182929; -.
DR OMA; HERVGWN; -.
DR OrthoDB; 4355748at2759; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0042627; C:chylomicron; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:Ensembl.
DR GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR GO; GO:0035473; F:lipase binding; IEA:Ensembl.
DR GO; GO:0060230; F:lipoprotein lipase activator activity; IEA:Ensembl.
DR GO; GO:0050750; F:low-density lipoprotein particle receptor binding; IEA:Ensembl.
DR GO; GO:0031210; F:phosphatidylcholine binding; IEA:Ensembl.
DR GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; IEA:Ensembl.
DR GO; GO:0010898; P:positive regulation of triglyceride catabolic process; IEA:Ensembl.
DR GO; GO:0010902; P:positive regulation of very-low-density lipoprotein particle remodeling; IEA:Ensembl.
DR GO; GO:0042246; P:tissue regeneration; IEA:Ensembl.
DR GO; GO:0019433; P:triglyceride catabolic process; IEA:Ensembl.
DR GO; GO:0070328; P:triglyceride homeostasis; IEA:Ensembl.
DR GO; GO:0034370; P:triglyceride-rich lipoprotein particle remodeling; IEA:Ensembl.
DR Gene3D; 1.20.120.20; Apolipoprotein; 2.
DR InterPro; IPR000074; ApoA_E.
DR PANTHER; PTHR18976; APOLIPOPROTEIN; 1.
DR PANTHER; PTHR18976:SF13; APOLIPOPROTEIN A-V; 1.
DR Pfam; PF01442; Apolipoprotein; 2.
DR SUPFAM; SSF58113; Apolipoprotein A-I; 1.
PE 3: Inferred from homology;
KW HDL {ECO:0000256|ARBA:ARBA00022850};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..366
FT /note="Apolipoprotein A-V"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014462094"
FT REGION 307..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 366 AA; 41282 MW; 360D114A7D3190BB CRC64;
MASMAAVLTW ALALLSAFSA TQARKGFWDY FRQTSGDKGR MEQIHQQKMA REPASLKDSL
EQDLNNMNKF LEKLGPLSGS EAPRLPRDPA GMRQQLQEEL EEVRARLQPY MAEAHELVGW
NLEGLRQQLK PYTMDLMEQV ALRVQELQEK LRVVGEDTKA QLLGGVGEAR ALLQELQSRV
VHHTGRFKEL FHPYAESLVS GIGRHVQELH HSVAPHTPAS PARLSRCVQV LSRKLTLKAK
ALHARIQQNL DQLREELSRT FAGTGAEQGA GPDPQMLSEE VRQRLQAFRQ DTYLQIAAFT
RAIDQETEEV QQQLAPPPPD HSAFAPEFGQ MDSDKALSKL QARLDDLWED ITYSLHDQGH
SHLGEP
//
