ID   A0A2K5DY21_AOTNA        Unreviewed;       394 AA.
AC   A0A2K5DY21;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=GDNF family receptor alpha like {ECO:0000313|Ensembl:ENSANAP00000025855.1};
GN   Name=GFRAL {ECO:0000313|Ensembl:ENSANAP00000025855.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000025855.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000025855.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GDNFR family.
CC       {ECO:0000256|ARBA:ARBA00005961}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_012297072.1; XM_012441649.1.
DR   AlphaFoldDB; A0A2K5DY21; -.
DR   STRING; 37293.ENSANAP00000025855; -.
DR   Ensembl; ENSANAT00000043779.1; ENSANAP00000025855.1; ENSANAG00000030650.1.
DR   GeneID; 105709648; -.
DR   CTD; 389400; -.
DR   GeneTree; ENSGT00730000111274; -.
DR   OMA; NVIHSCR; -.
DR   OrthoDB; 3043164at2759; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0016167; F:glial cell-derived neurotrophic factor receptor activity; IEA:Ensembl.
DR   GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR   GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR   GO; GO:0002023; P:reduction of food intake in response to dietary excess; IEA:Ensembl.
DR   GO; GO:0031098; P:stress-activated protein kinase signaling cascade; IEA:Ensembl.
DR   InterPro; IPR016017; GDNF/GAS1.
DR   InterPro; IPR037193; GDNF_alpha.
DR   InterPro; IPR003438; GDNF_rcpt.
DR   PANTHER; PTHR10269:SF1; GDNF FAMILY RECEPTOR ALPHA-LIKE; 1.
DR   PANTHER; PTHR10269; GDNF RECEPTOR ALPHA; 1.
DR   Pfam; PF02351; GDNF; 2.
DR   SMART; SM00907; GDNF; 3.
DR   SUPFAM; SSF110035; GDNF receptor-like; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..394
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014409013"
FT   TRANSMEM        352..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          24..101
FT                   /note="GDNF/GAS1"
FT                   /evidence="ECO:0000259|SMART:SM00907"
FT   DOMAIN          131..210
FT                   /note="GDNF/GAS1"
FT                   /evidence="ECO:0000259|SMART:SM00907"
FT   DOMAIN          220..316
FT                   /note="GDNF/GAS1"
FT                   /evidence="ECO:0000259|SMART:SM00907"
SQ   SEQUENCE   394 AA;  44413 MW;  E59EC93CC088F110 CRC64;
     MIVLIFLAVG LSLENEYTSQ SNNCTYLRQQ CLRDTNGCKH AWRVMEDACS DSDPGDTCKM
     RNSSYCNLSI QYLVESNFQF KECLCTDDFS CTVNKLLGKK CINKSDNMKE DKFKWNLTTP
     SHGGFKRMWS CLEVAEACVG DVVCNAQLAS YLKACSANGN PCDVKHCQAA IRFFYQNIPF
     NVAQMLAFCD CTQSDIPCQQ SKEALHSKPC AMNMVPPPTC LSVIHSCQND ELCRRHYRTF
     QSKCWQRVTR KCHEDENCIS ALSKQDLTCS GNDDCKAAYI NILGTILQVQ CTCRTITPSE
     ESLCKIFQHM LHRKSCFNYP TLSNVKGMAL YTRKHAKKIT LTGFHSPFSG EVIYAAMCMT
     VTCGILLLVM VKLRTSRISN KTRDPSPIQI PGEL
//