ID   A0A2K5DYH6_AOTNA        Unreviewed;       940 AA.
AC   A0A2K5DYH6;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN   Name=UNC5D {ECO:0000313|Ensembl:ENSANAP00000026049.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000026049.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000026049.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC       repulsion of neuronal growth cones in the developing nervous system
CC       upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC       ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the unc-5 family.
CC       {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR   AlphaFoldDB; A0A2K5DYH6; -.
DR   Ensembl; ENSANAT00000043973.1; ENSANAP00000026049.1; ENSANAG00000030465.1.
DR   GeneTree; ENSGT00950000182815; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   CDD; cd08801; Death_UNC5D; 1.
DR   Gene3D; 2.60.220.30; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR037936; UNC5.
DR   InterPro; IPR042058; UNC5D_Death.
DR   InterPro; IPR033772; UPA.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR   PANTHER; PTHR12582:SF5; NETRIN RECEPTOR UNC5D; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF00090; TSP_1; 2.
DR   Pfam; PF17217; UPA; 1.
DR   Pfam; PF00791; ZU5; 1.
DR   PRINTS; PR01705; TSP1REPEAT.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00209; TSP1; 2.
DR   SMART; SM00218; ZU5; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 2.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50092; TSP1; 2.
DR   PROSITE; PS51145; ZU5; 1.
PE   3: Inferred from homology;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW   ECO:0000256|RuleBase:RU367033};
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW   ECO:0000256|RuleBase:RU367033};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU367033};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU367033}.
FT   TRANSMEM        367..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU367033"
FT   DOMAIN          153..231
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          529..669
FT                   /note="ZU5"
FT                   /evidence="ECO:0000259|PROSITE:PS51145"
SQ   SEQUENCE   940 AA;  104827 MW;  DFAE02CBAAE51670 CRC64;
     EGCWGQRVSR GLCSDVLFDF TGTDNSEVLP ESIPSAPGTL PHFIEEPDDA YIIKSNPIAL
     RCKARPAMQI FFKCNGEWVH QNEHVSEESL DESSGLKVRE VFINVTRQQV EDFHGPEDYW
     CQCVAWSHLG TSKSRKASVR IAYLRKNFEQ DPQGREVPIE GMIVLHCRPP EGVPAAEVEW
     LKNEEPIDSE QDENIDTRAD HNLIIRQARL SDSGNYTCMA ANIVAKRRSL SATVVVYVNG
     GWSSWTEWSA CNVRCGRGWQ KRSRTCTNPA PLNGGAFCEG MSVQKITCTS LCPVDGSWEV
     WSEWSVCSPE CEHLRIRECT APAPRNGGKF CEGLSQESEN CTDGLCILDK KPLHEIKPQS
     IESASDIALY SGLGAAVVAV AVLVIGVTLY RRSQSDYGVD VIDSSALTGG FQTFNFKTVR
     QGNSLLLNSA MQPDLTVSRT YSGPICLQDP LDKELMTESS LFNPLSDIKV KVQSSFMVSL
     GVSERAEYHG KNHSRTFPHG NNHSFSTMHP RNKMPYIQNL SSLPTRTELR TTGVFGHLGG
     RLVMPNTGVS LLIPHGAIPE ENSWEIYMSI NQGEPSLQSD GSEVLLSPEV TCGPPDMIVT
     TPFALTIPHC ADVSSEHWNI HLKKRTQQGK WEEVMSVEDE STSCYCLLDP FACHVLLDSF
     GTYALTGEPI TDCAVKQLKV AVFGCMSCNS LDYNLRVYCV DNTPCAFQEV VSDERHQGGQ
     LLEEPKLLHF KGNTFSLQIS VLDIPPFLWR IKPFTACQEV PFSRVWCSNR QPLHCAFSLE
     RYTPTTTQLS CKICIRQLKG HEQILQVQTS ILESEREAIT FFAQEDSTFP AQTGPKAFKI
     PYSIRQRICA TFDTPNAKGK DWQMLAQKNS INRNLSYFAT QSSPSAVILN LWEARHQHDG
     DLDSLACALE EIGRTHTKLS NISESQLDEA DFNYSRQNGL
//