ID   A0A2K5E0Q4_AOTNA        Unreviewed;       151 AA.
AC   A0A2K5E0Q4;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=N-terminal E2 ubiquitin-conjugating enzyme {ECO:0000256|ARBA:ARBA00042168};
DE            EC=2.3.2.23 {ECO:0000256|ARBA:ARBA00012486};
DE            EC=2.3.2.25 {ECO:0000256|ARBA:ARBA00039075};
GN   Name=UBE2W {ECO:0000313|Ensembl:ENSANAP00000026733.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000026733.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000026733.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine +
CC         [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-
CC         activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-
CC         conjugating enzyme]-L-cysteine.; EC=2.3.2.23;
CC         Evidence={ECO:0000256|ARBA:ARBA00000485};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine +
CC         [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating
CC         enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].;
CC         EC=2.3.2.25; Evidence={ECO:0000256|ARBA:ARBA00035805};
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DR   AlphaFoldDB; A0A2K5E0Q4; -.
DR   Ensembl; ENSANAT00000044681.1; ENSANAP00000026733.1; ENSANAG00000031093.1.
DR   GeneTree; ENSGT00940000156908; -.
DR   OMA; HNVESVC; -.
DR   Proteomes; UP000233020; Unplaced.
DR   CDD; cd00195; UBCc; 1.
DR   Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR   InterPro; IPR000608; UBQ-conjugat_E2.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   PANTHER; PTHR24067; UBIQUITIN-CONJUGATING ENZYME E2; 1.
DR   PANTHER; PTHR24067:SF373; UBIQUITIN-CONJUGATING ENZYME E2 W; 1.
DR   Pfam; PF00179; UQ_con; 1.
DR   SMART; SM00212; UBCc; 1.
DR   SUPFAM; SSF54495; UBC-like; 1.
DR   PROSITE; PS50127; UBC_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT   DOMAIN          1..151
FT                   /note="UBC core"
FT                   /evidence="ECO:0000259|PROSITE:PS50127"
SQ   SEQUENCE   151 AA;  17251 MW;  A071476C693A8CD4 CRC64;
     MAGKRLQKEL LALQNDPPPG MTLNEKSVQN SITQWIVDME GAPGTLYEGE KFQLLFKFSS
     RYPFDSPQVM FTGENIPVHP HVYSNGHICL SILTEDWSPA LSVQSVCLSI ISMLSSCKEK
     RRPPDNSFYV RTCNKNPKKT KWCYWETCCL K
//