ID A0A2K5E3Q8_AOTNA Unreviewed; 440 AA.
AC A0A2K5E3Q8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Metaxin-1 {ECO:0000256|ARBA:ARBA00039748};
DE AltName: Full=Mitochondrial outer membrane import complex protein 1 {ECO:0000256|ARBA:ARBA00042095};
GN Name=MTX1 {ECO:0000313|Ensembl:ENSANAP00000027841.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000027841.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000027841.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Involved in transport of proteins into the mitochondrion.
CC Essential for embryonic development. {ECO:0000256|ARBA:ARBA00037753}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004294}.
CC -!- SIMILARITY: Belongs to the metaxin family.
CC {ECO:0000256|ARBA:ARBA00009170}.
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DR AlphaFoldDB; A0A2K5E3Q8; -.
DR STRING; 37293.ENSANAP00000027841; -.
DR Ensembl; ENSANAT00000045863.1; ENSANAP00000027841.1; ENSANAG00000031773.1.
DR GeneTree; ENSGT00950000182919; -.
DR OMA; TIDYDCA; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0001401; C:SAM complex; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd03212; GST_C_Metaxin1_3; 1.
DR CDD; cd03078; GST_N_Metaxin1_like; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR033468; Metaxin_GST.
DR InterPro; IPR019564; Sam37/metaxin_N.
DR PANTHER; PTHR12289; METAXIN RELATED; 1.
DR PANTHER; PTHR12289:SF34; METAXIN-1; 1.
DR Pfam; PF17171; GST_C_6; 1.
DR Pfam; PF10568; Tom37; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG01180; SUF1; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT TRANSMEM 395..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 146..267
FT /note="Mitochondrial outer membrane transport complex
FT Sam37/metaxin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10568"
FT DOMAIN 297..360
FT /note="Metaxin glutathione S-transferase"
FT /evidence="ECO:0000259|Pfam:PF17171"
FT REGION 1..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 440 AA; 48122 MW; F65698BD2C0C8780 CRC64;
MLLGGPPPRS PRSGTSPEGP QSSTGHVQFG KSPQTWPRRT RPHSPGPAAP TGRRDFPRRA
WLTARGPVPR SAAASRARRS LASPGTSPGP LPATTRGAVA GGGSVQGRAG AQKEVFPGQR
AGKMAAPMEL FCWSGGWGLP SVDLDSLAVL TYARFTGAPL KVHKISNPWR SPSGTLPALR
TSHGEVISVP HKIITHLRKE KYNADYDLSA RQGADTLAFM SLLEEKLLPV LVHTFWIDTK
NYVEVTRKWC AEAMPFPLNF FLPGRMQRQY MERLQLLSGE HRPEDEEELE KELYREAREC
LTLLSQRLGP QKFFFGDAPA SLDAFVFSYL ALLLQAKLPS GKLQAHLQGL HNLCAYCTHI
LSLYFPWDGA EVPPPRQTPA GPETEEEPYG RRNQILSVLA GLAAMVGYAL LSGIVSIQRA
TPARAPGTRA LGMAEEDEEE
//
