ID A0A2K5E6G2_AOTNA Unreviewed; 549 AA.
AC A0A2K5E6G2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Potassium voltage-gated channel subfamily KQT member 1 {ECO:0000256|ARBA:ARBA00019342};
DE AltName: Full=IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 {ECO:0000256|ARBA:ARBA00032659};
DE AltName: Full=KQT-like 1 {ECO:0000256|ARBA:ARBA00029687};
DE AltName: Full=Voltage-gated potassium channel subunit Kv7.1 {ECO:0000256|ARBA:ARBA00030121};
GN Name=KCNQ1 {ECO:0000313|Ensembl:ENSANAP00000028753.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000028753.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000028753.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004156}. Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane raft
CC {ECO:0000256|ARBA:ARBA00004285}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the potassium channel family. KQT (TC 1.A.1.15)
CC subfamily. Kv7.1/KCNQ1 sub-subfamily. {ECO:0000256|ARBA:ARBA00009499}.
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DR AlphaFoldDB; A0A2K5E6G2; -.
DR Ensembl; ENSANAT00000046779.1; ENSANAP00000028753.1; ENSANAG00000032186.1.
DR GeneTree; ENSGT00940000161001; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR InterPro; IPR005827; K_chnl_volt-dep_KCQN1.
DR PANTHER; PTHR47735:SF6; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 1; 1.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03520; KCNQ_channel; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01460; KCNQ1CHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..549
FT /note="Potassium voltage-gated channel subfamily KQT member
FT 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014416600"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..231
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 378..490
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 492..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 549 AA; 61540 MW; 352AFD009C72E075 CRC64;
MDFLIVLVCL IFSVLSTIEQ YAALATGTLF WMEIVLVVFF GTEYMVRLWS AGCRSKYVGL
WGRLRFARKP ISIIDLIVVV ASMVVLCVGS KGQVFATSAI RGIRFLQILR MLHVDRQGGT
WRLLGSVVFI HRQELITTLY IGFLGLIFSS YFVYLAEKDA VNESGRVEFG SYADALWWGV
VTVTTIGYGD KVPQTWVGKT IASCFSVFAI SFFALPAGIL GSGFALKVQQ KQRQKHFNRQ
IPAAASLIQT AWRCYAAENP DSSTWKIYIR KPPRSHTLLS PSPKPKKSVV VKKKKFKLDK
DNGVSPGEKT LTVPQITCDP PEERRLDHFS VDGYDSSVRK SPTLLEVSMP HFMRTNSFAE
DLDLEGETLL TPITHISQLR EHHRATIKVI RRMQYFVAKK KFQQARKPYD VRDVIEQYSQ
GHLNLMVRIK ELQRRLDQSI GKPSLFIAVS EKSKDRGSNT IGARLNRVED KVTQLDQRLV
LITDMLHQLL SLHRGGPPGG SGPPREGGAH ITQPCGSGGS IDPELFLPSN ALPTYEQLTV
PRRGPDEGS
//
