ID   A0A2K5E9Z3_AOTNA        Unreviewed;       523 AA.
AC   A0A2K5E9Z3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Nectin cell adhesion molecule 2 {ECO:0000313|Ensembl:ENSANAP00000029980.1};
GN   Name=NECTIN2 {ECO:0000313|Ensembl:ENSANAP00000029980.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000029980.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000029980.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K5E9Z3; -.
DR   STRING; 37293.ENSANAP00000029980; -.
DR   Ensembl; ENSANAT00000048011.1; ENSANAP00000029980.1; ENSANAG00000032757.1.
DR   GeneTree; ENSGT00940000161167; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0044291; C:cell-cell contact zone; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0005915; C:zonula adherens; IEA:Ensembl.
DR   GO; GO:0050839; F:cell adhesion molecule binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0001675; P:acrosome assembly; IEA:Ensembl.
DR   GO; GO:0044782; P:cilium organization; IEA:Ensembl.
DR   GO; GO:0046814; P:coreceptor-mediated virion attachment to host cell; IEA:Ensembl.
DR   GO; GO:0007010; P:cytoskeleton organization; IEA:Ensembl.
DR   GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR   GO; GO:0051654; P:establishment of mitochondrion localization; IEA:Ensembl.
DR   GO; GO:0009566; P:fertilization; IEA:Ensembl.
DR   GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:Ensembl.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:Ensembl.
DR   GO; GO:0002891; P:positive regulation of immunoglobulin mediated immune response; IEA:Ensembl.
DR   GO; GO:0033005; P:positive regulation of mast cell activation; IEA:Ensembl.
DR   GO; GO:0002860; P:positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; IEA:Ensembl.
DR   GO; GO:0050862; P:positive regulation of T cell receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0046596; P:regulation of viral entry into host cell; IEA:Ensembl.
DR   GO; GO:0030382; P:sperm mitochondrion organization; IEA:Ensembl.
DR   GO; GO:0007289; P:spermatid nucleus differentiation; IEA:Ensembl.
DR   GO; GO:0042271; P:susceptibility to natural killer cell mediated cytotoxicity; IEA:Ensembl.
DR   GO; GO:0060370; P:susceptibility to T cell mediated cytotoxicity; IEA:Ensembl.
DR   CDD; cd07703; IgC1_2_Nectin-2_Necl-5_like; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR   InterPro; IPR013162; CD80_C2-set.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   PANTHER; PTHR47387; NECTIN-2; 1.
DR   PANTHER; PTHR47387:SF1; NECTIN-2; 1.
DR   Pfam; PF08205; C2-set_2; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 3.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          34..145
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          167..261
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   REGION          373..404
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   523 AA;  56920 MW;  3F70812FFBBBC23D CRC64;
     RIQTREVWAT LSPYCTAVQP FLLLFILKMR KHGPGAQDVR VQVLPEVRGQ LGGTVELPCH
     LLPPLPGLFV SLVTWERSDV PVKQQNVAAF HPKLGASFPS PQPGSERLSF VSAKQSTGQD
     TEAELQDATL ALQGLTVEDE GNYTCEFATF PKGPVRGLTS LRVIATPQNH AEAQEVTLSP
     DPAPVARCIS KEGRPPARIS WLSSLDGEAK ETQVPGTLAG TVTVTSRFIL VPLGRADGVT
     VTCKVEHESL EEPVLIPVTL SVRYPPEVSI SGYDDNWYLG RTDATLSCDV RSNPEPTGYD
     WSGVRPLVGD LRTFICTVTN AVGTGRAEQV IFVRGEDPNT AAAGARAAIW GHHRFLIATA
     VAATGILICR QQRKEQTTAR AERTKSNLEG PPSYKPPTPK AKLEEQEMPS QLFTLGASEH
     SPLKTPYFDA GISCTDQEMP RYHELPTLEE RSGPLHPGAT SLGSPILVPP GPPAVEAISL
     DLEDEEEEEE EEDYLDKINP VYDALPSDSY QDKGFVMSRA MYV
//