ID A0A2K5EA14_AOTNA Unreviewed; 391 AA.
AC A0A2K5EA14;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Lysosomal acid phosphatase {ECO:0000256|ARBA:ARBA00039422};
DE EC=3.1.3.2 {ECO:0000256|ARBA:ARBA00012646};
GN Name=ACP2 {ECO:0000313|Ensembl:ENSANAP00000030009.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000030009.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000030009.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome lumen {ECO:0000256|ARBA:ARBA00004227}.
CC Lysosome membrane {ECO:0000256|ARBA:ARBA00037852}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00037852}; Lumenal side
CC {ECO:0000256|ARBA:ARBA00037852}.
CC -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC {ECO:0000256|ARBA:ARBA00005375}.
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DR AlphaFoldDB; A0A2K5EA14; -.
DR Ensembl; ENSANAT00000048040.1; ENSANAP00000030009.1; ENSANAG00000032696.1.
DR GeneTree; ENSGT00940000158446; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR CDD; cd07061; HP_HAP_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR033379; Acid_Pase_AS.
DR InterPro; IPR000560; His_Pase_clade-2.
DR InterPro; IPR029033; His_PPase_superfam.
DR PANTHER; PTHR11567; ACID PHOSPHATASE-RELATED; 1.
DR PANTHER; PTHR11567:SF180; LYSOSOMAL ACID PHOSPHATASE; 1.
DR Pfam; PF00328; His_Phos_2; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR PROSITE; PS00778; HIS_ACID_PHOSPHAT_2; 1.
PE 3: Inferred from homology;
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..391
FT /note="Lysosomal acid phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014381309"
FT TRANSMEM 349..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 391 AA; 44627 MW; 8E509D970C3963E7 CRC64;
MAGKRSGWNR VALLQLLLGV NLMVMPPTQA RSLRFVTLEG MLQHWELGQA LRQRYHGFLN
TSYHRQEVYV RSTDFDRTLM SAEANLAGLF PPNGMQRFNP NISWQPIPVH TVPMAEDRLL
KFPLGPCPRY EQLQNETRQT PEYQNESSRN AQFLDMVANE TGLTDLTLEN IWNVYDTLFC
EQTHGLRLPP WASPQTMQRL SRLKDFSFRF LFGIYQQAEK ARLQGGVLLA QIRKNLTLMA
TTSQLPKLLV YSAHDTTLVA LQMALDVYNG EQAPYASCHI FELYQEDSGN FSVEMYFRNE
SERAPWPLSL PGCPHRCPLQ DFLRLTEPVV PKDWQQECQL ASGPADTEVI VALAVCGSIL
FLLIVLLLTV LFRMQAQPPG YRHVADGEDH A
//
