ID A0A2K5EAA8_AOTNA Unreviewed; 1344 AA.
AC A0A2K5EAA8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=WRN {ECO:0000313|Ensembl:ENSANAP00000030099.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000030099.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000030099.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR Ensembl; ENSANAT00000048132.1; ENSANAP00000030099.1; ENSANAG00000032806.1.
DR GeneTree; ENSGT00940000159168; -.
DR OMA; TSQDFGP; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd18017; DEXHc_RecQ3; 1.
DR CDD; cd06129; RNaseD_like; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR029491; Helicase_HTH.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR PANTHER; PTHR13710:SF120; WERNER SYNDROME ATP-DEPENDENT HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF14493; HTH_40; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT DOMAIN 556..722
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 747..898
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1149..1228
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 483..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..508
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..524
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1344 AA; 152418 MW; 1B478EB8F04BCC8E CRC64;
MNEKKLETTP QQWKCPERMS VQNKRCAVEE RKACVQKSVF EDDLPFLEFT GSIVYSYEAS
DGSFLSEDIS MSLSDGDVVG FDMEWPPVYN KGKLGKVALI QLCVSESKCY LFHISSMSVF
PQGLKMLLEN KAIKKAGVGI EGDQWKLLRD FDVKLENFVE LTDVANKKLK CIETWSLNGL
VKHLLGKQLL KDKSIRCSNW SKFPLTEDQK LYAATDAYAG FIISRKLEIM DDALQMFAIN
KEEEIQLSDM KKQLTSISEE VMDLAKHLPD TFSKLENPRR VSILLKDISE NLYSLRKMIF
TSTNMETELR PSRNLNSLSF EDSTAGAVQQ KQIREHKNFI NLEDETWDPT LDHLAKHDGE
DVLGNKVKRK EDRFEDGVED NKLKENTERA CLMSLAITEH ELQILEQQAQ EEYLSNTAYK
STECLSPNDN EKDTSYIIES DEDLEMEMLK HLSPNDNEND TSYVIESDED LEMEMLKSLE
NLNSGTVEPT HSKCLEMERN LSLPTKEEDD ENEANEEEED DDKDSLLPAP NAEQITCLKT
YFGHSSFKPV QWKVIHSILE ERRDNVAVMA TGYGKSLCFQ YPPLYVGKIG LVISPLISLM
EDQVLQLRMS NIPACFLGSA QSEDVLRDVK IGKYRIVYIT PEYCSGNLSL LQQLEADIGI
TLIAVDEAHC ISEWGHDFRN SFRKLGSLKT TLPLVPIVAV TATASSSIRQ DIVCCLNLKN
PQITCTGFDR PNLYLEVGRK TGNILEDLKP FLVRKTNTCW EFEGPTIIYC PSRKMTEQVT
AELRKLKLSC GTYHAGMSFS QRKDTHHRFV RDEIQCVIAT IAFGMGINKA DIRQVIHYGA
PKEMESYYQE IGRAGRDGLQ SSCHVLWAPA DINLNRLLLA EIHNETFRLY KLKMMSKMEK
YLHSSRCRRR IILSHFEDKQ VQKASLGITG TEKCCDNCRS RLGHCYSMDD SEDASWDFGP
QAFQLLSAVD ILGEKFGIGL PILFLRGSNS QRLADQYRRH SLFGTGKDQA ESWWKAFSHQ
LIIEGFLVEV SGRNKFVKIC MLTKKGRNWL HKANTESQSL VLQANEELCP KKFLLPSSKT
VSSDTKQHSY NQVPVELTAE KKSNLEKLYS YKPCDKISSG SSISKKSIMV QSLEKFHSAS
EPVISAQEQE TQTVLYGKLV EARQKQANKM DVPPAILATN KILVDMAKMR PTTVADVKRI
DGVSEGKAAM LAPLLEVIKH FCQTKSVQTD LFSSTKPQEE QKMSLVAKNK ISTLSQSMAI
TYSLFQEKKM PLKSIAESRI LPLMTVGMHL SQAVKAGCPL DLERAGLTPE VQKIIADVIR
NPPINSDFIC REKEKITCMV CRRK
//
