ID   A0A2K5ECC9_AOTNA        Unreviewed;       563 AA.
AC   A0A2K5ECC9;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=Centromere protein T {ECO:0000256|ARBA:ARBA00016401};
GN   Name=CENPT {ECO:0000313|Ensembl:ENSANAP00000030819.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000030819.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000030819.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC       {ECO:0000256|ARBA:ARBA00004629}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the CENP-T/CNN1 family.
CC       {ECO:0000256|ARBA:ARBA00010137}.
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DR   RefSeq; XP_012323607.1; XM_012468184.1.
DR   AlphaFoldDB; A0A2K5ECC9; -.
DR   STRING; 37293.ENSANAP00000030819; -.
DR   Ensembl; ENSANAT00000048858.1; ENSANAP00000030819.1; ENSANAG00000033134.1.
DR   GeneID; 105727971; -.
DR   CTD; 80152; -.
DR   GeneTree; ENSGT00390000003044; -.
DR   OrthoDB; 2919543at2759; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0000939; C:inner kinetochore; IEA:Ensembl.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:Ensembl.
DR   GO; GO:0051382; P:kinetochore assembly; IEA:Ensembl.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR   Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR   InterPro; IPR028255; CENP-T.
DR   InterPro; IPR035425; CENP-T/H4_C.
DR   InterPro; IPR032373; CENP-T_N.
DR   InterPro; IPR009072; Histone-fold.
DR   PANTHER; PTHR46904; CENTROMERE PROTEIN T; 1.
DR   PANTHER; PTHR46904:SF1; CENTROMERE PROTEIN T; 1.
DR   Pfam; PF15511; CENP-T_C; 1.
DR   Pfam; PF16171; CENP-T_N; 1.
DR   SUPFAM; SSF47113; Histone-fold; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Centromere {ECO:0000256|ARBA:ARBA00023328};
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT   DOMAIN          1..417
FT                   /note="Centromere kinetochore component CENP-T N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16171"
FT   DOMAIN          458..553
FT                   /note="CENP-T/Histone H4 histone fold"
FT                   /evidence="ECO:0000259|Pfam:PF15511"
FT   REGION          1..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          316..459
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..31
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        330..345
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        361..375
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   563 AA;  61269 MW;  2FA487925CC2AE16 CRC64;
     MADHDPDSDS TPRTLLRRVL DTADPRTPRR PRSARAGAQR RALLETASSR RSSSQTKMTT
     RRHSHGARSI SRSAYVQASG HLKEQTPRTL LKNILLTAPE SSILMPKSVV KPVPAPQVVQ
     PSRRESSLGS LELQLPELEP PTTLAPGLLA PGRRKQRLRL SMFQQGVDQG LPLSQEPQRN
     ADASSLTSSL NLTFATPLQP QSVQRPGLAR RPPARRAVDV GAFLQDLRDT SLAPPNIVLE
     DTQPFSQPTV GCSPRVYRSP PCMPHTGAED TELAAGCKKR SSGPGMQTNS PEKPAQFLAG
     EAEEVDAFAL DFLSTSSGVS GEDGVEPLQD GVEEAEKRME EEGVSVSEME ATGAQGPSRA
     EEPEGHTEVT EAEESQGTAE AKGPGASSGD EDASDRAARP ELVSSTPESL QARRHHQFLE
     PDPPPGAAVL SSEPAEPLLV RRPPRPGTTG PRPQQDPHKA GLSHYVKFFS FYAKMPMERK
     ALEMVEKCLD KYFQHLCDDL EVFAAHAGRK TVKPEDVELL MRRQGLVTDQ VSLHVLVERY
     LPLEYRQLLI PCASSGNSVF PAQ
//