ID A0A2K5ED65_AOTNA Unreviewed; 841 AA.
AC A0A2K5ED65;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Taste 1 receptor member 1 {ECO:0000313|Ensembl:ENSANAP00000031104.1};
GN Name=TAS1R1 {ECO:0000313|Ensembl:ENSANAP00000031104.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000031104.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000031104.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_012329072.1; XM_012473649.1.
DR AlphaFoldDB; A0A2K5ED65; -.
DR STRING; 37293.ENSANAP00000031104; -.
DR Ensembl; ENSANAT00000049148.1; ENSANAP00000031104.1; ENSANAG00000033293.1.
DR GeneID; 105731765; -.
DR CTD; 80835; -.
DR GeneTree; ENSGT00940000161264; -.
DR OMA; EDWAIST; -.
DR OrthoDB; 4096532at2759; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; IEA:Ensembl.
DR GO; GO:0050917; P:sensory perception of umami taste; IEA:Ensembl.
DR CDD; cd06363; PBP1_taste_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF3; TASTE RECEPTOR TYPE 1 MEMBER 1; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..841
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014358498"
FT TRANSMEM 568..592
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 604..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 635..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 681..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 724..749
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 761..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 789..809
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 566..831
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 841 AA; 92890 MW; 190F4B2620666FD4 CRC64;
MLPCIAHLAG LQLFISCCRA FACHSTESSP DFSLPGDYLL GGLFPLHSGC LQVRHRPEVT
LCDRLGTFND HGYHLFQAMR LGVEEINNST ALLPNVTLGY ELYDVCSDSA NVYATLRMLS
LQGPHHIKLQ GDLLQYSPKV LAVIGTDNTN QAATTAALLS PFLVPLISYA ASSTTLSMKQ
QYPSFLRTIP SDKYQVETMV LLLQRFGWTW ISLIGSSGDY GQLGVQALED QATVQGICIA
FKDIVPFSAR VGDERMQGMM HHLVQARATV VVVFSSRPLA RVFFESVVLA NVTGKVWIAS
EDWAISTYIS GVPGIRRIGT VLGVAIQQRT IPGLKAFEEA YASADKGAPR PCPKGSWCSS
NQLCRECQAF TAHGMPKLTA FSMSAAYNAY QAVYAVAHGL HQLLGCASGA CSRDQVYPWQ
LLEQIQKVNF LLHGDTVMFH DNGNPFSSYN IIAWDWNGPK WTFTVVGSST WSPVQLDINE
TKIQWHGKDN QVPKSVCSSD CLEGHQRVVM GFHHCCFKCV PCEAGTFLNT SDLYRCQPCG
KEEWAPNGSQ TCFPRTVVFL AWHEYTSWVL LAANTLLLLL LLGTAGLFAW HLDTPVVRSA
GGQLCFLMLG SLAAGSGSLY GFFGEPTWPA CLLRQALFAL GFTIFLSCVT VRSFQLVIIF
KFSTKVPTFY HAWVQNHGAS LFVMISSVAQ LLICLTWLVV WTPLPTREYQ RFPQLVVLEC
TEANSLGFIL AFLYNGLLSV SAFACSYLGK DLPENYNEAK CVTFSLLFNF VSWIAFFTTA
SVYDGKYLPA VNMLAVLSSL SSGFGGYFLP KCYVILCRPD LNSTEHFQAS IQDYTRRRSS
T
//
