ID A0A2K5ED75_AOTNA Unreviewed; 995 AA.
AC A0A2K5ED75;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Neurofilament heavy chain {ECO:0000313|Ensembl:ENSANAP00000031166.1};
GN Name=NEFH {ECO:0000313|Ensembl:ENSANAP00000031166.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000031166.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000031166.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; A0A2K5ED75; -.
DR STRING; 37293.ENSANAP00000031166; -.
DR Ensembl; ENSANAT00000049210.1; ENSANAP00000031166.1; ENSANAG00000033321.1.
DR GeneTree; ENSGT00940000161893; -.
DR OMA; FHSWTRT; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0030424; C:axon; IEA:Ensembl.
DR GO; GO:0097418; C:neurofibrillary tangle; IEA:Ensembl.
DR GO; GO:0005883; C:neurofilament; IEA:Ensembl.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0099160; C:postsynaptic intermediate filament cytoskeleton; IEA:Ensembl.
DR GO; GO:0098685; C:Schaffer collateral - CA1 synapse; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0099184; F:structural constituent of postsynaptic intermediate filament cytoskeleton; IEA:Ensembl.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0033693; P:neurofilament bundle assembly; IEA:Ensembl.
DR GO; GO:0060052; P:neurofilament cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0048936; P:peripheral nervous system neuron axonogenesis; IEA:Ensembl.
DR GO; GO:0099170; P:postsynaptic modulation of chemical synaptic transmission; IEA:Ensembl.
DR GO; GO:1902513; P:regulation of organelle transport along microtubule; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR010790; DUF1388.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR033183; NF-H.
DR PANTHER; PTHR23214:SF1; NEUROFILAMENT HEAVY POLYPEPTIDE; 1.
DR PANTHER; PTHR23214; NEUROFILAMENT TRIPLET H PROTEIN; 1.
DR Pfam; PF07142; DUF1388; 3.
DR Pfam; PF00038; Filament; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT DOMAIN 97..413
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 58..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 101..135
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 178..226
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 297..384
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 462..494
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..995
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 995 AA; 108480 MW; 40976BB006DD0452 CRC64;
MMSFGGADAL LGAPFAPLHG GGSLHYALAR KGGAGGTRSA AGSSSGFHSW TRTSVSSVSA
SPSRFRGAGA ASSTDSLDTL SNGPEGCVVA AAAARSEKEQ LQALNDRFAG YIDKVRQLEA
HNRSLEGEAA ALRQQQAGRA AMGELYEREV REMRGAVLRL GAARGQLRLE QEHLLEDIAH
VRQRLDDEAR QREEAEAAAR ALARFAQEAD AARVELQKKA QALQEECGYL RRHHQEEVGE
LLGQIQGCGA AQAQVQADAR DALKCDVTSA LREIRAQLEG HAVQSTLQSE EWFRVRLDRL
SEAAKVNTDA MRSAQEEITE YRRQLQARTT ELEALKSTKD SLERQRSELE DRHQADISSY
QEAIQQLDAE LRNTKWEMAA QLREYQDLLN VKMALDIEIA AYRKLLEGEE CRIGFGPIPF
SLPEGLPKIP SVSTHIKVKS EEKIKVVEKS EKETVIVEEQ TEETQVTEEV TEEEEKEAKE
EEGKEEEGAE EEEAERGREE AKSPPAEEAA SPEKEAKSPV KEEAKSPAEA KSPEKEEAKS
PAEVKSPEKA KSPAKEEAKS PAEAKSPEKE EAKSPAEVKS PEKAKSPAKE EAKSPVEAKS
PEKAKSPAKE EAKSPAEAKS PEKEEAKSPA EVKSPEKAKS PAKEEAKSPV EAKSPEKAKS
PAEAKSPVKK EAKSPAEVKS PEKAKSPVKE EAKSPEKAKS PEKEEAKSPA EVKSPEKAKS
PVKEEAKSPE KAKTLDVKSP EAKTPAKEEA KSPADKSPEK AKSPVKEEVK SPEKAKSPLK
EDAKAPEKEI PKKEEVKSPV KEEKPQEVKV KEPPKKAEEK APTTPKTEKD SKKEEAPKKE
APKPEVKKEP AIEKPKESKV EAKKEEAEDK KKAATPEKEA PAKAAVKEDA KPKEKTEVAK
KEPDDAKAKE PSKPAEKEAA AAAPEKKDSK EEKATEAKKP DEKPKTEAKA KEDDKTLSKE
PSKPKAEKAE KSSSTDQKDS TPPEKATEDK AAKGK
//
