ID A0A2K5EDV8_AOTNA Unreviewed; 1992 AA.
AC A0A2K5EDV8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRB {ECO:0000313|Ensembl:ENSANAP00000031402.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000031402.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000031402.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 3 subfamily. {ECO:0000256|ARBA:ARBA00025789}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSANAT00000049446.1; ENSANAP00000031402.1; ENSANAG00000033249.1.
DR GeneTree; ENSGT00940000156088; -.
DR OMA; TRHQTNT; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 13.
DR CDD; cd14617; R-PTPc-B; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 15.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR041201; PTPRJ_TM.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF2; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE BETA; 1.
DR Pfam; PF00041; fn3; 16.
DR Pfam; PF18861; PTP_tm; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 17.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 16.
DR PROSITE; PS50853; FN3; 10.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1992
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014373691"
FT DOMAIN 113..206
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 292..379
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 380..469
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 470..556
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 643..734
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 735..821
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 822..912
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 995..1088
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1261..1357
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1358..1449
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1698..1958
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1873..1949
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1992 AA; 223855 MW; F9F5E5B78DCA6550 CRC64;
MLSHGAGLAL WIALSLLRTG LGEPERCNFT LVESKVSSHS VSIQWRILGP PCNFSLIYSS
DTLGGAWCHP FRIDNTTYGC NLHDLQAGTI YNFRIVSLDG EERTVDLQTD PLPPARFGIS
KEKTTSTSLH VWWTPSSGKV TWYEVQLFDE NNQEIQGFQI QESTSWNEYT FFSLTAGSKY
NITITAISGE KRSSSVYTSG STVPSPVKDI GISTRANSLL ISWSHGSGNV EQYRLTLMDK
GILVQGGVVD KHATSYAFHG LTPGYIYNLT VVTEAAGLQN YRWKLIRTAP MEVSNLKVIN
DGSLTSLKVK WQRPPGNVDS YNITLSHKGI IKESRVLAPR VTETHFKELT PGRLYQVTVS
CVSGELSAQK MAVGRTFPDK VANLEANSNG WMRSLAVSWS PPTGDWEQYR ILLFNDSVVL
LNVTVGKEET HYVMDDMGLI PGRQYEVEVT VESGNLKNSE RCQGRTVPLA VFQLRVKHAN
ETSLSIMWQT PVAEWEKYII SLADRDLLLI HKSLSKDAKE FTFTDLVPGR KYMATVTSIS
GDLKNSSSVK GRTVPAQVTD LHVANQGMTS SLFTNWTQAQ GDADFYQVLL IHENVVIKNE
SISSETSRYS FHSLKSGSLY SVVVTTVSGG ISSRQVVVEG RTVPSSVSGV TVNNSGRNDY
LSVSWLLAPG DVDNYEVTLS HDSKVVQSLV IAKSVRECSF SSLTPGRLYT VTITTRSGKY
ENHSFSQERT VPDKVQGVSV SNSARSDYLR VSWVHATGDF DHYDVTIKNK DNFIQTKSIS
KSENECVFVQ LVPGRLYSVT VTTKSGQYEA SEQGNGRTIP EPVKDLTLRN RSTEDLHVTW
SRANGDVDQY EIQLLFNDMK VFPPFHLVNT ATEYRFTSLT PGRQYKILVL TISGDVQQSA
FIEGFTVPSA VKNIRISPNG ATDSLTVNWT PGGGDVDSYT VSAFRHSQKV DSQTVPKHIF
AHTFHRLEAG EEYQIMIASV SGSLKNQINA GGRTVPASVQ GVIADNAYSS HSLIVSWQKA
AGVAERYDIL LLNDNGILMR NTSEPATTKQ HKFEDLTPGK KYKIQILTVS GGLFSKEAQT
EGRTVPAAVT DLRITENSTR HLSFRWTASE GELSWYNIFL YNPDGNLQER AQVDPQVQSF
SFQNLLQGRM YKMVIVTHSG ELSNESFIFG RTVPASVSHL RGSNRNMTDS LWFSWSPASG
DFDFYELILY NPNGTKKENW KDKHLTEWRF HGLVPGRKYT LWVVTHSGDL SNKVTAESRT
APSPPSLMSF ADIANTSLAI TWKGPPDWTE YNDFELQWLP RDALTVFNPY NNRKSEGRIV
YGLRPGRSYQ FSVKTVSGDS WKTYSKPIFG SVRTKPDKIQ NLHCRPQNST AIACSWIPPD
SDFDGYSIEC RKMDTQEVEF SRKLEKEKSL LNIMMLVPHK RYLVSIKVQS AGMTSEVVED
STITMIDRPP PPPPHIRVNE KDVLISKSSI NFTVNCSWFS DTNGAVKYFT VVVREADGSD
ELKPEQQHPL PSYLEYRHNA SIRVYQTNYF ASKCAENPDS NSKSFNINLG AEMESLGGKC
DPTQQKFCDG PLKPHTAYRI SIRAFTQLFD EDLKEFTKPL YSDTFFSLPI TTESEPLFGA
IEGVSAGLFL IGMLVAVVAV LICRQKVSHG GERPSARLSI RRDRPLSVHL NLGQKGPIKI
NQFEGHFMKL QADSNYLLSK EYEELKDVGR NQSCDIALLP ENRGKNRYNN ILPYDASRVK
LSNVDDDPCS DYINASYIPG NNFRREYIVT QGPLPGTKDD FWKMVWEQNV HNIVMVTQCV
EKGRVKCDHY WPADQDSLYY GDLILQMLSE SVLPEWTIRE FKICTEEQLD AHRLIRHFHY
TVWPDHGVPE TTQSLIQFVR TVRDYINRSP GAGPTVVHCS AGVGRTGTFI ALDRILQQLD
SKDTVDIYGA VHDLRLHRVH MVQTECQYVY LHQCVRDVLR ARKLRSEQEN PLFPIYENVN
PEYHRDPVYS RH
//
