ID A0A2K5EEC0_AOTNA Unreviewed; 660 AA.
AC A0A2K5EEC0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Rho GTPase activating protein 27 {ECO:0000313|Ensembl:ENSANAP00000031577.1};
GN Name=ARHGAP27 {ECO:0000313|Ensembl:ENSANAP00000031577.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000031577.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000031577.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K5EEC0; -.
DR Ensembl; ENSANAT00000049622.1; ENSANAP00000031577.1; ENSANAG00000033399.1.
DR GeneTree; ENSGT00950000182860; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13233; PH_ARHGAP9-like; 1.
DR CDD; cd04403; RhoGAP_ARHGAP27_15_12_9; 1.
DR CDD; cd00201; WW; 3.
DR Gene3D; 2.20.70.10; -; 3.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR23176:SF104; RHO GTPASE-ACTIVATING PROTEIN 27; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00397; WW; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00456; WW; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 3.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT DOMAIN 44..72
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 91..125
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 209..236
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 266..382
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 468..657
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 24..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 660 AA; 74221 MW; A553480A34A30CF8 CRC64;
VSILEGFLLP QVDDPPEPVY ANIERQPRAT SPGASAAPLP SPVWETHTDA GTGRPYYYNP
DTGVTTWESP FEAAEGAASP ATSPASVGSH VSFETEWGQY WDEESRRVFF YNPLTGETAW
EDEAEDEPEE ELEMQPGLSP GSPRNPRPPT PETDYPESLT SYPEEDYSPV GSFSEPGPTS
PLSTPPGWSC HVSQDKQTVY TNHFTQEQWV RLEDPHGKPY FYNPEDSSVR WELPQVPVPA
PRSIHKSSQD SDTPAQSSPP EEKTKTLEKA GVLHRTKTAD KGKRLRKKHW SASWTVLEGG
VLTFFKDSKT SAAGGLRQPS KFSTPEYTVE LRGASLSWAP KDKSSKKNVL ELRSRDGSEY
LIQHDSEAII STWHKAITQG IQELSAELPL EEESESSSVD FGSSERLGSW QEKEEDARPS
AAAPALGPGG LESDLSKVRH KLRKFLQRRP TLQSLREKGY IKDQVFGCAL AALCERERSR
VPRFVQQCIR AVEARGLDID GLYRISGNLA TIQKLRYKVD HDERLDLEDG RWEDVHVITG
ALKLFFRELP EPLFPFSHFR QFIAAIKLQD QAQRSRCVRD LVRSLPAPNH DTLRLLFQHL
CRVIEHGEQN RMSVQSVAIV FGPTLLRPEV EETSMPMTMV FQNQVVELIL QQCNDIFPPH
//
