ID A0A2K5EEW0_AOTNA Unreviewed; 840 AA.
AC A0A2K5EEW0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Rho GTPase activating protein 42 {ECO:0000313|Ensembl:ENSANAP00000031746.1};
GN Name=ARHGAP42 {ECO:0000313|Ensembl:ENSANAP00000031746.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000031746.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000031746.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5EEW0; -.
DR Ensembl; ENSANAT00000049791.1; ENSANAP00000031746.1; ENSANAG00000033530.1.
DR GeneTree; ENSGT00940000155492; -.
DR OMA; CASQERY; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01249; BAR-PH_GRAF_family; 1.
DR CDD; cd04374; RhoGAP_Graf; 1.
DR CDD; cd12066; SH3_GRAF3; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047234; GRAF_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047225; PH_GRAF.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12552; OLIGOPHRENIN 1; 1.
DR PANTHER; PTHR12552:SF3; RHO GTPASE-ACTIVATING PROTEIN 42; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 231..340
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 342..538
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 782..840
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 541..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 191..225
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 550..564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..654
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 840 AA; 94426 MW; 22E1D1C34582707B CRC64;
MGLPTLEFSD SYLDSPDFRE RLQCHEIELE RTNKFIKELI KDGSLLIGAL RNLSMAVQKF
SQSLQDFQFE CIGDAETDDE ISIAQSLKEF ARLLIAVEEE RRRLIQNAND VLIAPLEKFR
KEQIGAAKAD TQIDREHQNF YEASLEYVFK IQEVQEKKKF EFVEPLLSFL QGLFTFYHEG
YELAQEFAPY KQQLQFNLQN TRNNFESTRQ EVERLMQRMK SANQDYRPPS QWTMEGYLYV
QEKRPLGFTW IKHYCTYDKG SKTFTMSVSE MKSSGKMNGL VSSSPEMFKL KSCIRRKTDS
IDKRFCFDIE VVERHGIITL QAFSEANRKL WLEAMDGKEP IYTLPAIISK KEEMYLNEAG
FNFVRKCIQA VETRGITILG LYRIGGVNSK VQKLMNTIFS PKSPPDVDID IELWDNKTIT
SGLKNYLRCL AEPLMTYKLH KDFIIAVKSD DQNYRVEAVH ALVHKLPEKN REMLDILIKH
LVKVSLHSQQ NLMTVSNLGV IFGPTLMRAQ EETVAAMMNI KFQNIVVEIL IEHYEKIFHT
APDPNIPLPQ PQSRSGSRRT RAICLSTGSR KPRGRYTPCL AEPDSDSYSS SPDSTPMGSI
ESLSSHSSEQ NSTTKSASCQ PREKSGGIPW IATPSSSNGQ KSLGLWTTSP ESSSREDATK
TDAESDCQSV ASVTSPGDVS PPIDLVKKGP YGLSGLKRAS AASLRSISAA EGNKSYSGSI
QSLTSVGSKE TPKASPNPDL PPKMCRRLRL DPASSNGYQR PGSVVAAKAQ LFENVGSPKP
VSSGRQAKAM YSCKAEHSHE LSFPQGAIFS NVYPSVEPGW LKATYEGKTG LVPENYVVFL
//
