ID A0A2K5EF91_AOTNA Unreviewed; 462 AA.
AC A0A2K5EF91;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Centrosomal protein 57 {ECO:0000313|Ensembl:ENSANAP00000031883.1};
GN Name=CEP57 {ECO:0000313|Ensembl:ENSANAP00000031883.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000031883.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000031883.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC -!- SIMILARITY: Belongs to the translokin family.
CC {ECO:0000256|ARBA:ARBA00008179}.
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DR RefSeq; XP_012310230.1; XM_012454807.1.
DR AlphaFoldDB; A0A2K5EF91; -.
DR Ensembl; ENSANAT00000049929.1; ENSANAP00000031883.1; ENSANAG00000033666.1.
DR GeneID; 105718947; -.
DR CTD; 9702; -.
DR GeneTree; ENSGT00530000063695; -.
DR OrthoDB; 5396442at2759; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR Gene3D; 1.20.58.90; -; 1.
DR InterPro; IPR025913; Cep57_CLD.
DR InterPro; IPR024957; Cep57_MT-bd_dom.
DR PANTHER; PTHR19336:SF11; CENTROSOMAL PROTEIN OF 57 KDA; 1.
DR PANTHER; PTHR19336; UNCHARACTERIZED DUF1167; 1.
DR Pfam; PF14073; Cep57_CLD; 1.
DR Pfam; PF06657; Cep57_MT_bd; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT DOMAIN 68..233
FT /note="Cep57 centrosome localisation"
FT /evidence="ECO:0000259|Pfam:PF14073"
FT DOMAIN 313..384
FT /note="Cep57 centrosome microtubule-binding"
FT /evidence="ECO:0000259|Pfam:PF06657"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 42..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 403..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 73..237
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 413..429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..445
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 462 AA; 52309 MW; F8547DBF8D29DAA5 CRC64;
MAAASVSAAS GSQFSNISAE PSRANGSMVR HSSSPYVVYP SDKPFLNSDL RRSPSKPTLA
YPESNSRAIF SALKNLQDKI HRLELERIQA EESVKTLSRE TIEYKKVLDE QIQERENSKN
EESKHNQELT SQLLAAENKC NLLEKQLEYM RNMIKHAEME RTSVLEKQVS LERERQHGQT
HVQSQLEKLD LLEQEYNKLT TMQALAEKKM QELEAKLHEE EQERKRMQAK AAEKSSKNYF
GAQPHYRLCL GDMPFVAGKS TSPSHAVVAN VQLVLHLMKQ HSKVLCNDRV VSSIPLAKQV
SSRGGKSKKL SVTPPSSSGI NEELSEVLQT LQDEFGQMTF DHQQLTKLIQ ESPTVELKEN
LECELEALVG RMEAKASQIT KVRKYQAQLE KQKLEKQKKE LKATKKTLDE EGNSSSRSSG
ITGTTNKKDF TKLRPGEKRR KNLQLLKDMQ TIQNSLQSSS LS
//
