ID A0A2K5EJH8_AOTNA Unreviewed; 739 AA.
AC A0A2K5EJH8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Zona pellucida sperm-binding protein 2 {ECO:0000256|ARBA:ARBA00040237};
DE AltName: Full=Zona pellucida glycoprotein 2 {ECO:0000256|ARBA:ARBA00042572};
DE AltName: Full=Zona pellucida protein A {ECO:0000256|ARBA:ARBA00042272};
GN Name=ZP2 {ECO:0000313|Ensembl:ENSANAP00000033370.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000033370.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000033370.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Zona pellucida
CC {ECO:0000256|ARBA:ARBA00024183}.
CC -!- SIMILARITY: Belongs to the ZP domain family. ZPA subfamily.
CC {ECO:0000256|ARBA:ARBA00038403}.
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DR AlphaFoldDB; A0A2K5EJH8; -.
DR STRING; 37293.ENSANAP00000033370; -.
DR Ensembl; ENSANAT00000051427.1; ENSANAP00000033370.1; ENSANAG00000034351.1.
DR GeneTree; ENSGT00940000160133; -.
DR OMA; RPYGDKE; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:Ensembl.
DR GO; GO:0035805; C:egg coat; IEA:UniProtKB-SubCell.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005771; C:multivesicular body; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032190; F:acrosin binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0035804; F:structural constituent of egg coat; IEA:Ensembl.
DR GO; GO:0007339; P:binding of sperm to zona pellucida; IEA:Ensembl.
DR GO; GO:0060468; P:prevention of polyspermy; IEA:Ensembl.
DR Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR InterPro; IPR042235; ZP-C.
DR InterPro; IPR048290; ZP_chr.
DR InterPro; IPR001507; ZP_dom.
DR InterPro; IPR017977; ZP_dom_CS.
DR PANTHER; PTHR23343; ZONA PELLUCIDA SPERM-BINDING PROTEIN; 1.
DR PANTHER; PTHR23343:SF4; ZONA PELLUCIDA SPERM-BINDING PROTEIN 2; 1.
DR Pfam; PF00100; Zona_pellucida; 1.
DR PRINTS; PR00023; ZPELLUCIDA.
DR SMART; SM00241; ZP; 1.
DR PROSITE; PS00682; ZP_1; 1.
DR PROSITE; PS51034; ZP_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Fertilization {ECO:0000256|ARBA:ARBA00023279};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 714..738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 366..632
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
FT REGION 675..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..699
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 739 AA; 81462 MW; E546F0BD3D94BC32 CRC64;
MASKQRGDSW SPPGWFSAGW STYRSIALFF TLVTSVNSIG ASQLVNPAFP GTVICDERGI
TVAFRSSPGT EKWHASVVDP FGLDMPNCPY LLDPEKLTMR ATYDNCTRRV HGGHQMTIKF
MNDDAAVRHG AVMYQFFCPA VQVEETHGLS AATTCKKDSM SFSLPRIFSG LADATQMGWS
IEVGDGAKAK TLTLSEAMME GFNLLFDNNR MTFHVPFNAT GVTHYVQGNS HLYMVSLKLT
FIAPGQKVIF SSRAICAPDP VTCNATHMTV TIPEFPGKLK SVSFGNQNIE VSQLHDSGID
LEATDGTKLH FSKTLLKTKL SEKCLLHQFY LASLKLTFLL WLETVSMVIH PECLCESPVS
IVTGEQCTQD GFMDFEVYSH QTQPALDLGT LRVGNSSCQP VFKAQSQGLV RFHVPLNGCG
TRYKFEDDKV IYENEIHAHW MDLPPSKISR DSEFRMTVKC SYSRNAMRLN INVESLTPPV
ASVRSGPFTL ILQSYPGNSY QQPYENNEYP LVRFLRQPIY MEVRVLNRDD PNIKLVLDDC
WATSTMDSDS LPKWNIVVDG CAYNLDNYLT TFHPVGSSVT HPDHFQRFDV KAFAFVSEAH
VLSSLVYFHC SVLICNRLSP DSPLCSVTCP VSSRHKRATG TTEAKTMTVS LPGPILLLSD
DSSFRGVGPS DLRLLKASGS RGEKSRSETR EEAGSQDVTD TKGHKTTGNV ASKAVAAVAA
VATLAGVVAT LGFICYLCN
//
