ID   A0A2K5EKI0_AOTNA        Unreviewed;      1099 AA.
AC   A0A2K5EKI0;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Calcium voltage-gated channel auxiliary subunit alpha2delta 2 {ECO:0000313|Ensembl:ENSANAP00000033676.1};
GN   Name=CACNA2D2 {ECO:0000313|Ensembl:ENSANAP00000033676.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000033676.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000033676.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta
CC       family. {ECO:0000256|ARBA:ARBA00007060}.
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DR   AlphaFoldDB; A0A2K5EKI0; -.
DR   Ensembl; ENSANAT00000051738.1; ENSANAP00000033676.1; ENSANAG00000034452.1.
DR   GeneTree; ENSGT00940000156238; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR   CDD; cd01463; vWA_VGCC_like; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013680; VDCC_a2/dsu.
DR   InterPro; IPR013608; VWA_N.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR   PANTHER; PTHR10166:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-2; 1.
DR   Pfam; PF08473; VGCC_alpha2; 1.
DR   Pfam; PF00092; VWA; 1.
DR   Pfam; PF08399; VWA_N; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022673};
KW   Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022882};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT   DOMAIN          242..420
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
SQ   SEQUENCE   1099 AA;  124753 MW;  33D1532390A5A7A9 CRC64;
     VVRRPTEAEL RHSEPLLPTR MQHWARRLEQ EVDGVMRIFG GVQQLREIYK DNRNLFEVQE
     NEPQKLVEKV AGDIESLLDR KVQALKRLAD AAENFQKAHR WQDNIKEEDI LYYDAKADAE
     LDDPESEDVE RGSKASTLRL DFIEDPNFKN KVNYSYTAVQ IPTDIYKGST VILNELNWTE
     ALENVFMENR RQDPTLLWQV FGSATGVTRY YPATPWRAPK KIDLYDVRRR PWYIQGASSP
     KDMVIIVDVS GSVSGLTLKL MKTSVCEMLD TLSDDDYVNV ASFNEKAQPV SCFTHLVQAN
     VRNKKVFKEA VQGMVAKGTT GYKAGFEYAF DQLQNSNITR ANCNKMIMMF TDGGEDRVQD
     VFEKYNWPNR TVRVFTFSVG QHNYDVTPLQ WMACANKGYY FEIPSIGAIR INTQEYLDVL
     GRPMVLAGKE AKQVQWTNVY EDALGLGLVV TGTLPVFNLT QDGPGEKKNQ LILGVMGIDV
     ALNDIKRLTP NYTLGANGYV FAIDLNGYVL LHPNLKPQTT NFREPVTLDF LDAELEDENK
     EEIRRSMIDG NKGHKQIRTL VKSLDERYID EVIRNYTWVP IRSTNYSLGL VLPPYSTFYL
     QANLSDQILQ VKCKWPDFEF LLPSSFESEG HVFIAPREYC KDLNASDNNT EFLKNFIELM
     EKVTPDSKQC NNFLLHNLIL DTGITQQLVE RVWRDQDLNT YSLLAVFAAT DGGITRVFPN
     KAAEDWTENP EPFNASFYRR SLDNHGYVFK PPHQDTLLRP LELENDTVGI LVSTAVELSL
     GRRTLRPAVV GVKLDLEAWA EKFKVLASNR THQDQPQKQC GPSSHCEMDC EVNNEDLLCV
     LIDDGGFLVL SNQNHQWDQV GRFFSEVDAN LMLALYNNSF YTRKESYDYQ AACAPQPPGN
     LGAAPRGVFV GMALSSADHL HSAPLPCRSL FQQLLYGLIY HSWFQADPAE AEGSPETRES
     SCVMKQAQYY FGSVNASYNA IIDCGNCSRL FHAQRLTNTN LLFVVAEKPL CSQCEAGRLL
     QKETHSDGPE QCELVQRPRY RRGPHICFDY NATEDTSDCG RGASFPPSLG VLVSLQLLLL
     LGLPPRPQPQ VQVHASRRL
//