ID A0A2K5EKI0_AOTNA Unreviewed; 1099 AA.
AC A0A2K5EKI0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Calcium voltage-gated channel auxiliary subunit alpha2delta 2 {ECO:0000313|Ensembl:ENSANAP00000033676.1};
GN Name=CACNA2D2 {ECO:0000313|Ensembl:ENSANAP00000033676.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000033676.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000033676.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta
CC family. {ECO:0000256|ARBA:ARBA00007060}.
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DR AlphaFoldDB; A0A2K5EKI0; -.
DR Ensembl; ENSANAT00000051738.1; ENSANAP00000033676.1; ENSANAG00000034452.1.
DR GeneTree; ENSGT00940000156238; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR CDD; cd01463; vWA_VGCC_like; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013680; VDCC_a2/dsu.
DR InterPro; IPR013608; VWA_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR PANTHER; PTHR10166:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-2; 1.
DR Pfam; PF08473; VGCC_alpha2; 1.
DR Pfam; PF00092; VWA; 1.
DR Pfam; PF08399; VWA_N; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022673};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022882};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT DOMAIN 242..420
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 1099 AA; 124753 MW; 33D1532390A5A7A9 CRC64;
VVRRPTEAEL RHSEPLLPTR MQHWARRLEQ EVDGVMRIFG GVQQLREIYK DNRNLFEVQE
NEPQKLVEKV AGDIESLLDR KVQALKRLAD AAENFQKAHR WQDNIKEEDI LYYDAKADAE
LDDPESEDVE RGSKASTLRL DFIEDPNFKN KVNYSYTAVQ IPTDIYKGST VILNELNWTE
ALENVFMENR RQDPTLLWQV FGSATGVTRY YPATPWRAPK KIDLYDVRRR PWYIQGASSP
KDMVIIVDVS GSVSGLTLKL MKTSVCEMLD TLSDDDYVNV ASFNEKAQPV SCFTHLVQAN
VRNKKVFKEA VQGMVAKGTT GYKAGFEYAF DQLQNSNITR ANCNKMIMMF TDGGEDRVQD
VFEKYNWPNR TVRVFTFSVG QHNYDVTPLQ WMACANKGYY FEIPSIGAIR INTQEYLDVL
GRPMVLAGKE AKQVQWTNVY EDALGLGLVV TGTLPVFNLT QDGPGEKKNQ LILGVMGIDV
ALNDIKRLTP NYTLGANGYV FAIDLNGYVL LHPNLKPQTT NFREPVTLDF LDAELEDENK
EEIRRSMIDG NKGHKQIRTL VKSLDERYID EVIRNYTWVP IRSTNYSLGL VLPPYSTFYL
QANLSDQILQ VKCKWPDFEF LLPSSFESEG HVFIAPREYC KDLNASDNNT EFLKNFIELM
EKVTPDSKQC NNFLLHNLIL DTGITQQLVE RVWRDQDLNT YSLLAVFAAT DGGITRVFPN
KAAEDWTENP EPFNASFYRR SLDNHGYVFK PPHQDTLLRP LELENDTVGI LVSTAVELSL
GRRTLRPAVV GVKLDLEAWA EKFKVLASNR THQDQPQKQC GPSSHCEMDC EVNNEDLLCV
LIDDGGFLVL SNQNHQWDQV GRFFSEVDAN LMLALYNNSF YTRKESYDYQ AACAPQPPGN
LGAAPRGVFV GMALSSADHL HSAPLPCRSL FQQLLYGLIY HSWFQADPAE AEGSPETRES
SCVMKQAQYY FGSVNASYNA IIDCGNCSRL FHAQRLTNTN LLFVVAEKPL CSQCEAGRLL
QKETHSDGPE QCELVQRPRY RRGPHICFDY NATEDTSDCG RGASFPPSLG VLVSLQLLLL
LGLPPRPQPQ VQVHASRRL
//