ID A0A2K5EKK7_AOTNA Unreviewed; 5481 AA.
AC A0A2K5EKK7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=PDZ domain-containing protein {ECO:0000259|PROSITE:PS50106};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000033758.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000033758.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR STRING; 37293.ENSANAP00000033758; -.
DR Ensembl; ENSANAT00000051820.1; ENSANAP00000033758.1; ENSANAG00000034540.1.
DR GeneTree; ENSGT00940000154902; -.
DR OMA; HENASDH; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0044291; C:cell-cell contact zone; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0045121; C:membrane raft; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0098797; C:plasma membrane protein complex; IEA:Ensembl.
DR GO; GO:0042383; C:sarcolemma; IEA:Ensembl.
DR GO; GO:0044548; F:S100 protein binding; IEA:Ensembl.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR23348:SF41; NEUROBLAST DIFFERENTIATION-ASSOCIATED PROTEIN AHNAK; 1.
DR PANTHER; PTHR23348; PERIAXIN/AHNAK; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT DOMAIN 1..75
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 547..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2420..2445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2475..2495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2612..2632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2671..2701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3318..3340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3398..3422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3460..3483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3716..3740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3782..3806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3835..3858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3963..3988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4030..4061
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4091..4121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4164..4195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4232..4254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5307..5394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5414..5481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2430..2445
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2686..2701
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3469..3483
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3782..3799
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3844..3858
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3972..3988
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4101..4121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5323..5337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5435..5464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5481 AA; 584692 MW; D561A08A30B716B1 CRC64;
MEKEEETTRE LLLPNWQGSG SHGLTIAQRD DGVFVQEVMQ NSPAARTGVV KEGDQIVGAT
IYFDNLQSDE VTQLLNTMGH HTVGLKLHRK GDRSPEPGQT WTHEVFSSRS SEVVLSGDDE
EYQRIYTTKI KPRLKSEDGV EGDLGETQSR TITVTRRVTA YTVDVTGREG AKDIDISSPE
FKIKIPRHEL TEISNVDVET QSGKTVIRLP SGFEAASATT GSAVDIRAGA ISASGPELQG
AGHSKLQVTM PGIKVGGSGV NVSAKGLDLG GGGGVQVPAL DISSSLGGGA VEVQGPSLES
GDHGKIKIPT MKMPKFGVST GPEGQTPEAG LRVSAPEVSV GHKGGKPGLT VQASQLEVSA
PSASIGGLEG KLKGPQITGP SLEGDLGLKG AKPQGSIGVH ASVPQIGGRI TGPNVEVQVP
DVDIHGTGSR LNLPEMKVPK FSVSGTKGEE IGIDVTLPTG EVAVPGVSGD ISLPEIATGG
LEGKVKGVKV KTPEMIVQKP KISMRDVDLS LGSSKLKGDI KVSAPGVQGD VKGPQVAVKG
SRVDIETPNL EGTLTGPRLG SPSGKTGTCS ISMAEVDLNV AAPKVKGGVD VTLPKVEGKV
QVPEGDVKGP KVDVSAPDVE VHGPEWNLKM PKMKMPTFGT LGAKGEGPDV HVTLPKGDVG
ISGPKVNVEA PDVNMEGLGG KLKGPDVKLP DVSVKTPKIS MPDVDLHVKG PKVKGEYDVT
VPKLEGELKG PKVDIDAPDM DVHGPDWHLK MPKMKMPKFS VPGIKAEGPE VDANLPKADV
DISRPKVDVS APDLSIEGPE GKLKGPKFKM PEMNIKVPKI SMPDVDLHLK GPNVKGEYDV
TVPKVEGDIK VPDVELKSAK VDIDAPDVEV QGPDWHLKMP KVKMPKFSMP GFKGEGPEVD
VNLPKADVDI SGPKVNVEVP DVNIEGPEGK LKDPKFKMPE MNIKAPKISM PDVDLHVKGP
KVKGEYDVTV PKLEGDLKGP KVDASAPDVE MQGPDWNLKM PKIKMPKFSM PSLKGEGPEL
DVNLSKANVD ISAPKVDISA PDLSLEGPEG KLKGPKFKMP EMHFKAPKMS LPDVDLDLKG
PKMKGNVDIS APKIEGEMQL PDVDIKGPKV DIKAPDVEGQ GPDWSLKIPK MKMPKFSMPS
LKGEGPEVDV NLPKADIVVS GPKVDVEAPD VNIEGPEGKL KGPKFKMPEM HFKAPKISMP
DVDLNLKGPK LKGDVDVSVP KVEGEMKVPD VDIKGPKVNI DAPDVEVQGP DWHLKMPKVK
MPKFNMPGFK GEGPEVDVNL PKADIDVSGP KVDVEVPDVN IEGPDVKLKG PKFKMPEMNI
KPQKISMPDV GLHLKSPKMK GDYDVTVPKV EGEIKAPDVD IKGPKVDMNA PDVDVHGPDW
HLKMPKVKMP KFSMPGFKGE GPEVDVKLPK ADLGVSGPKV DIDVPDVNLE APEGKLKGPK
FKMPSMNIQT HKISMPDVGL NLKAPKLKTD VDVSLPKVEG DLKGPEIDVK APKMDVNVGD
IDIEGSEGKL KGPKFKMPEM HFKVEGEMKV PDVDIKGPKV DIDAPDMDIH GPDWHLKMPK
MKMPKFSMPG FKAEGPEVDV NLPKAVDVDV PDVSLEGPEG KLKGPKFKMP EMHFKAPKIS
MPDVDLNLKG PKLKGDVDVS VPKVEGEMKV PEVDIKGPRV DIDTPDVDVH GPDWHLKMPK
VKMPKFSMPG FKGEGPEVDV NLPKADIDVS GPTVDIDAPD LDIEGPEGKL KGSKFKMPKL
NIKAPKISMP DVDLNLKGPK LKGEIDASVP ELEVDIKGPS VDVEVPDVDL ECPDAKLKGP
KFKMPEMHFK APKISMPDVD LHLKGRKVKG DVDVSVPKVE GEMKVPDVDI KGPKVDIDVP
DVDVHGPDWH LKMPKMKMPK FSMPGFKAEG PEVDVNLPKA DIDVSGPKVD VDIPDVSLEG
PEGKLKGPKF KMPEMHFKAP KISMPDVDLH LKGPKVKGDV DVSVPKLEGE LTGPSVDVEV
PDVELECPDA KLKGPKFKMP DMHFKTPKIS MPDVDLHLKG PKVKGDVDVS APKLEGELTG
PSVDVEVPDV ELECPDAKLK GPKFKMPDMH FKAPKISMPD VNLKGPKVKG DVDVSVPKIE
GEMKMKMPKF SMPGPKVDVD VPDVSLEGPE GKLKGPKFKM PEMHFKGPKI KGDVDVSLKG
PELDVKGPKL DVDMPEVAME GPDGKWKTPK FKMPDMHFKA PNISMPDVDL NLKGPKIKGD
VDVSVHEVEG KIEVPDVNIK GTKLDVNAPD VEGPDWHLKM PKMKMPKFSM PGFKAEGPEI
NVNLPKADID VSGPKMDIEG PDVNIEGPEG KLKGPKFKMP EMNIKAPKIS MPDFDLHLKG
PKVKGDVDVS LPKVEGDLKG PEVGIKGPKV DIDVPDVGVQ GPDWHLKMPK MKMPKFSMPG
FKGEGPDVDM NLPKADLDVS GPKVDVDVPD VNIEGPEGKL KGPKFKMPEM NIKAPKISMP
DIDLNLKGPK VKGDMDVSLP KVEGDLKGPE VDIKGPKLDI EAPDVDVHGP DWHLKMPKIK
MPKISMPGFK GEGPEVDVNL PKADLNVSGS KVDVECPDVN IEGPEGKWKS PKFKMPEMHF
KTPKISMPDI DLNLTGPKIK GDVDVTGPKV EGDMKGPEVD LQGPKVDIDV PDVNVQGPDW
HLKMPKMKMP KFSMPGFKTE GPEVDVNLPK ADVDVSGPKV DIEGPDVNIE GPEGKLKGPK
FKMPEMNIKA PKISMPDFDL HLKGPKVKGD VDISLPKVEG DLKGPEVDIK GPKVDIDAPD
VDVQGPDWHL KMPKVKMPKF SMPGFKGEEG PDVDVNLPKA DLDVSGPKVD IDVPDVNIEG
PDAKLKGPKF KMPEMNIKAP KISMPDLDLN LKGPKMKGEV DVSLPNVEGD LKGPALDIKG
PKIDVDAPGI DIHGPDGKLK GPKLKMPDMH VNMPKISMPE IDLNLKGPKL KGDVDVSVPK
LEGEIKAPSL DVKGPEVDVS GPKLNIEGKS KKSRFKLPKF NFSGSKVQTP EVDVKGKKPD
IDITGPKVDI NAPDVEVQGK VKGSKFKMPF LSISSPKVSM PDVELNLKGP KVKGDLDVAG
PNLEGDFKGP KVDVKVPEVN LNAPDVDVHG PDWNLKMPKM KMPKFSVPGL KAEGPDVAVD
LPKGDINIEG PSMNIEGPEL NVEGPEGGLK GPKFKMPDMN IKAPKISMPD LDLNLKGPKV
KGDVDVSLPK LEGDLKGPEV DIKGPKVDIS APDVDVHGPD WHLKMPKVKM PKFSMPGFKG
EGPEVDVNLP KADLDVSGLK VDVDVPDVNI EGPDAKLKGP KFKMPEMNIK APKISMPDFD
LNLKGPKMKG DVDVSLPKVE GDLKGPDVDI KGPKVDIDTP DINIEGPEGK LKGPKFKMPE
MHLKAPKISM PDIDLNLKGP KVKGDVDVSL PKVEGDLRGP EVDIKGPKVD INAPDVDVQG
PDWHLKMPKV KMPKFSMPGF KGEGPDVDVN LPKADLDVSG PKVDVDVPDV NIEGPDAKMR
GPKFKMPEMN IKAPKISMPD FDLNLKGPKV KGDVDLSLPK VEGDVKVPDV DIKGPKVDIN
APDVDVQGPD WHLKMPKIKM PKISMPGFKG EGPDVDVNLP KADLDVSGPK VDVDVPDVNI
EGPDAKLKGP KFKMPEMNIK APKISMPDFD LHLKGPKVKG DVDVSLPKME GDLKAPEVDI
KGPKVDIDAP DVDVHGPDWH LKMPKVKMPK FSMPGFKGEG PEVDVNLPKA DIDVSGPKVD
IDTPDIDIHG PEGKLKGPKF KMPDLHLKAP KISMPEVDLN LKGPKVKSDV DVSLPKVEGD
LKGPEVDVKG PKVDIDTGTE MPKVKYGPSF SMPGFKGEGP DVDVNLPKAD LDVSGPKVDV
DVPDVNIEGP DAKMRGPKFK MPEMNIKAPK ISMPDFDLHL KGPKVKGDVD VSLPKVEGDL
KGPEVDIKGP KVDIDAPDVD VHGPDWHLKM PKVKMPKFSM PGFKGEGPDV DVTLPKADID
VSGPKVDIDA PDVSIEGPDA KLKGPKFKMP DMNIKAPKIS MPDIDFNLKG PKVKGDVDVS
LPKVEGDLKG PEIDIKGPSL DIDTPDVNIE GPEGKLKGPK FKMPEMNIKA PKISMPDFDL
HLKGPKVKGD ANVSLPKVEG DLKGPEIDIE GPEGKLKGPK FKMPDVHFKT PQISMSDIDL
NLKGPKIKGD MDISVPKLEG DLKGPKVDVK GPNLDIDTPD IDIHGPEGKL KGPKFKMPDL
HLKAPKISMP EVDLNLKGPK VKSDVDVSLP KVEGDLKGPE VDVKGPKVDI DVPDMDVHGP
DWHLKMPKVK MPKFSMPGFK GEGPDADLDV SGPKVDIDVP DVNIEGPDAK LKGPKFRMPE
MNIKAPKISM PDIDLNLKGP KVKGDVDVSL PKVEGDLKGP EVDIKGPKLD IDAPDVDVHG
PDWHLKMPKV KMPKFSMPGF KGEGPDVDVN LPKADLDVSG PKVDVDVPDV NIEGPDAKLK
GPKFKMPEIN IKAPKISMPD VDLDLKGPKV RGDFDVSVPK VEGTLKGPDV DLKGPSLDFE
GPDAKLSGPS LKMPSLEISA PKVSAPDVDL HLKAPKIGFS GPKLEGGEVD LKGPKVEAPS
LDVHMDSPDI NIEGPDVKIP KFKKPKFGFG AKSPKADIKS PSLDVTVPEA ELNLETPEIS
VGGKGKKSKF KMPKIHMSGP KIKAKKQGFD VNVPGGEIDA SLKAPDVDVN IAGPDAALKV
DVKSPKTKKP MFGKMYFPDV EFDIKSPKFK AEASLPSPKL EGELQAPDLE LSSPGIHFEG
PDIKAKAPKV KMPGVDISVP KIEGDLKGPK VQANLDAPDI NIEGPDAKVK TPSFGISAPQ
VSIPDVNVNL KGPKIKGDVP SVGLEGPDVD LQGPEAKIKF PKFSMPKIGV PGVKMEGGGA
EVRGQLPSLE GDLRGPDVKL EGPDVSLKGP GVDLPSVKLS MPKVSGPDLD LNLKGPSLKG
DLDASVPSVK VQAPGLDLSG VGGKVQVGGD GVKVPGIDVT TTLNVGAPDV TLRGPSLQGD
LAVSGDIKCP KVSVGAPDLS LDASEGGIKL PKMKLPQFGI STPGSDLHVK GPQVSGELKG
PQISAPNVDL NLEGPKVKGS LGVTGEMKGP TVGGGVPGLE GNLQMPGIKS SGCDVNLPGV
NVKLPTGKIS GPEIKGDLKG SEVGFHGAAP DISVRGPSFN MASPESDFGI SLKGPKIKGG
VDVSGGVSAP DISLGEGHVS VKGSGGEWKG PQVSSALNLD TSKFAGSLHF SGPKVDGGVK
GGQIGLQAPG LSASGPQGHL ESGSGKVTFP KMRMPKFTFS GRELVGREVG VDIHFPKAEA
SVQPGAGQGE WEESEVKLKK AKIKMPKFNF SKPKGKGGVT GSPEASISGS KGDLKSSKAS
LGSLEGEAEG EASSPKGKFS LFKSKKPRHR SNSFSDEREF SAPSTPTGTL EFEGGEVSLE
GGKVKGKQGK LKFGTFGGLG SKSKGHYEVT GSDDETGKLQ GSGVSLASKK SRLSSSSSND
SGPKVGIQLP EVELSVSTKK E
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