ID A0A2K5EKV9_AOTNA Unreviewed; 761 AA.
AC A0A2K5EKV9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=THAP domain containing 12 {ECO:0000313|Ensembl:ENSANAP00000033801.1};
GN Name=THAP12 {ECO:0000313|Ensembl:ENSANAP00000033801.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000033801.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000033801.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_012325062.1; XM_012469639.1.
DR AlphaFoldDB; A0A2K5EKV9; -.
DR Ensembl; ENSANAT00000051863.1; ENSANAP00000033801.1; ENSANAG00000034553.1.
DR GeneID; 105729005; -.
DR CTD; 5612; -.
DR GeneTree; ENSGT00530000063516; -.
DR OMA; SCALNIW; -.
DR OrthoDB; 3405036at2759; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR008906; HATC_C_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR006612; THAP_Znf.
DR PANTHER; PTHR46289:SF16; 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE; 1.
DR PANTHER; PTHR46289; 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED; 1.
DR Pfam; PF05699; Dimer_Tnp_hAT; 1.
DR Pfam; PF05485; THAP; 1.
DR SMART; SM00692; DM3; 1.
DR SMART; SM00980; THAP; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50950; ZF_THAP; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00309};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00309};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00309};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00309}.
FT DOMAIN 1..86
FT /note="THAP-type"
FT /evidence="ECO:0000259|PROSITE:PS50950"
FT REGION 123..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 761 AA; 87630 MW; 98F9A393F46EE8FC CRC64;
MPNFCAAPNC TRKSTQSDLA FFRFPRDPAR CQKWVENCRR ADLEDKTPDQ LNKHYRLCAK
HFETSMICRT SPYRTVLRDN AIPTIFDLTS HLNNPHSRHR KRIKELSEDE IRTLKQKKID
EISEQEQKHK ETNNSNAQNP SEEGGEGQDE DILPLTLEEK ENKEYLKSLF EILILMGKQN
IPLDGHEADE IPEGLFTPDN FQALLECRIN SGEEVLRKRF ETTAVNTLFC SKTQQRQMLE
ICESCIREET LREVRDSHFF SIITDDVVDI AGEEHLPVLV RFVDESHNLR EEFVGFLPYE
ADAEILAVKF HTMITEKWGL NMEYCRGQAY IVSSGFSSKM KVVASRLLEK YPQAIYTLCS
SCALNMWLAK SVPVMGVSVA LGTIEEVCSF FHRSPQLLLE LDNVISVLFQ NSKERGKELK
EICHSQWTGR HDAFEILVEL LQALVLCLDG INSDTNIRWN NCIAGRAFVL CSAVTDFDFI
VTIVVLKNVL SFTRAFGKNL QGQTSDVFFA AGSLTAVLHS LNEVMENIEV YHEFWFEEAT
NLATKLDIQM KLPGKFRRAH QGNLESQLTS ESYYKETLSV PTVEHIIQEL KDIFSEQHLK
ALKCLSLVPS VMGQLKFNTS EEHHADMYRS DLPNPDTLSA ELHCWRIKWK HRGKDIELPS
TIYEALHLPD IKFFPNVYAL LKVLCILPVM KVENERYENG RKRLKAYLRN TLTDQRSSNL
ALLNINFDIK HDLDLMVDTY IKLYTSKSEL PTENSETMEN T
//
