ID A0A2K5EN60_AOTNA Unreviewed; 1098 AA.
AC A0A2K5EN60;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=RB transcriptional corepressor like 2 {ECO:0000313|Ensembl:ENSANAP00000034643.1};
GN Name=RBL2 {ECO:0000313|Ensembl:ENSANAP00000034643.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000034643.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000034643.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR AlphaFoldDB; A0A2K5EN60; -.
DR Ensembl; ENSANAT00000052707.1; ENSANAP00000034643.1; ENSANAG00000034864.1.
DR GeneTree; ENSGT00950000183202; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20606; CYCLIN_RBL2; 1.
DR CDD; cd00043; CYCLIN_SF; 1.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 3.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR015030; RB_C.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR PANTHER; PTHR13742:SF8; RETINOBLASTOMA-LIKE PROTEIN 2; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SMART; SM01369; Rb_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 3.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 48..135
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 98..246
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 375..567
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT DOMAIN 807..893
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 979..1098
FT /note="Retinoblastoma-associated protein C-terminal"
FT /evidence="ECO:0000259|SMART:SM01369"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 768..790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 892..957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1098 AA; 123589 MW; 6965334808CE9594 CRC64;
MPSGGDQSPP PPPPPPAAAA ASDEEEDDDG EAEDAAPPAE SPTPQIQQRF DELCSRLNMD
EAARAEAWDS YRSMSESYTL EGNDLHWLAC ALYVACRKSV PTVSKGTVEG NYVSLTRILK
CSEQSLIEFF NKMKKWEDMA NLPPHFRERT ERLERNFTVS AVIFKKYEPI FQDIFKYPQE
EQPRQQRGRK QRRQPCTVSE IFHFCWVLFI YAKGLSEDFH AKDSKPSSDP PCIIEKLCSL
HDGLVLEAKG IKEHFWKPYI RKLYEKKLLK GKEENLTGFL EPGNFGESFK AINKAYEEYV
LSVGNLDERI FLGEDAEEEI GTLSRCLNTG SGTETAERVQ MKNILQQHFD KSKAPRISTP
LTGVRYVKEN SPCVTPVSTA THSLSRLHTM LTGLRNAPSE KLEQILRTCS RDPSQAIANR
LKEMFEIYSQ HFQPDEDFSN CAKEIASKHF RFAEMLYYKV LESVIEQEQK RLGDMDLSGI
LEQDAFHRSL LACCLEVVTF SYKPPGNFPF ITEIFDVPLY HFYKVIEVFI RAEDGLCREV
VKHLNQIEEQ ILDHLAWKPE SPLWEKIRDN ENRVPTCEEV MPPQNLEKAD EICIAGSPLT
PRRVTEVRAD TGGLGRSITS PTTLYDRYSS PPASTTRRRL FVENDSPSDG GTPGRMPPQP
IVNAVPVQNV SGEPVSVTPV PGQTLVTMAT ATVTANNGQT VTIPVQGIAN ENGGITFYPV
QVNVGGQAQA VTGSIQPLSA QALAGSLSSQ QVTGTTLQVP GQVAIQQISP GGQQQKQGQS
VSSSSNRPRK TSSLSLFFRK VYHLAGVRLR DLCAKLDISD ELRKKIWTCF EFSIIQCPEL
MMDRHLDQLL MCAIYVMAKV TKEDKSFQNI MRCYRTQPQA RSQVYRSVLI KGKRKRRNSG
SSDSRSHQNS PTELNKDRTS RDSSPVMRSS STLPVPQPSS APPTPTHLTG ANSDMEEEER
GDLIQFYNNI YIKQIKTFAL KYSQANVMDV PPLSPYPFVR TGSPRRVQLS QNHPVYISPH
KNEAMLSPRE KIFYYFSNSP SKRLREINSM IRTGETPTKK RGILLEDGSE SPAKRICPEN
HSALLRRLQD VANDRGSH
//
